3 mL urine in a sterile collection container. Clearly label container as urine. Refrigerate.
Minimum Volume
0.6 mL Urine
Transport Temperature
Refrigerated
Rejection Criteria
Plasma Serum Whole Blood Please Refer To Unit Code 5661
Specimen Stability
3 Days Room Temperature 1 Week Refrigerated 2 Weeks Frozen
Additional Information
BK virus infections can be a significant cause of morbidity and mortality in immunocompromised patients with hematologic and renal transplants. Clinical manifestation of BK infections include tubulointerstitial nephritis, also referred to as BK virus nephropathy (BKVN), and ureteral stenosis in kidney transplant recipients and hemorrhagic cystitis in bone marrow transplant recipients. Approximately 1-10% of renal transplant patients progress to BKVN and up to 80% of these patients may lose their grafts. The onset of nephritis can occur as early as several days post-transplantation to as late as 5 years, with a mean period of 10 to 13 months post-transplantation. The majority of BKVN manifestations occur within the first 2 years post-transplantation.
A presumptive diagnosis of BKVN can be established if a patient has persistent viruria of greater than 10,000 copies/mL of BK virus DNA in plasma for more than two weeks. Hence, monitoring BK virus burden in patients who are at risk of developing BKVN is helpful in predicting the onset of nephropathy.
The quantitative range of the BK virus PCR assay is 2.3 log IU/mL (200 IU/mL) to 7.3 log IU/mL (20,000,000 IU/mL). Samples in which virus is detected below the limit of quantitation are reported as "Detected" without a reported quantity. BK virus viral load test results are reported in International Units per milliliter (IU/mL) and copies/mL as well as log transformed values. Results may not be comparable to results generated by other methodologies not calibrated to international standards (IU/mL).
Reference Range
Not Detected
Methodology
Polymerase Chain Reaction (PCR)
CPT and LOINC
87799 Laboratory Developed Test By Srl. LOINC: Bkv Urine Quant: 32285-9 Bvk Urine Viral Log: Not Available Bkv Urine Quant Copies: 41480-5 Bkv Urine Log Copies: 90924-2 Bkv Urine Interp: 33978-8
CPT Codes
87799 Laboratory Developed Test By Srl.
LOINC
33978-8
32285-9
41480-5
90924-2
Test Setup Days Performed
Varies AM Shift
Expected Turnaround Time
3-6 Days
Performing Lab
Sonic Reference Laboratory Inc.
Ordering/Specimen
Collect
0
Preferred Specimen Requirements
3 mL urine in a sterile collection container. Clearly label container as urine. Refrigerate.
Minimum Volume
0.6 mL Urine
Transport Temperature
Refrigerated
Rejection Criteria
Plasma Serum Whole Blood Please Refer To Unit Code 5661
Specimen Stability
3 Days Room Temperature 1 Week Refrigerated 2 Weeks Frozen
Clinical Information
Additional Information
BK virus infections can be a significant cause of morbidity and mortality in immunocompromised patients with hematologic and renal transplants. Clinical manifestation of BK infections include tubulointerstitial nephritis, also referred to as BK virus nephropathy (BKVN), and ureteral stenosis in kidney transplant recipients and hemorrhagic cystitis in bone marrow transplant recipients. Approximately 1-10% of renal transplant patients progress to BKVN and up to 80% of these patients may lose their grafts. The onset of nephritis can occur as early as several days post-transplantation to as late as 5 years, with a mean period of 10 to 13 months post-transplantation. The majority of BKVN manifestations occur within the first 2 years post-transplantation.
A presumptive diagnosis of BKVN can be established if a patient has persistent viruria of greater than 10,000 copies/mL of BK virus DNA in plasma for more than two weeks. Hence, monitoring BK virus burden in patients who are at risk of developing BKVN is helpful in predicting the onset of nephropathy.
The quantitative range of the BK virus PCR assay is 2.3 log IU/mL (200 IU/mL) to 7.3 log IU/mL (20,000,000 IU/mL). Samples in which virus is detected below the limit of quantitation are reported as "Detected" without a reported quantity. BK virus viral load test results are reported in International Units per milliliter (IU/mL) and copies/mL as well as log transformed values. Results may not be comparable to results generated by other methodologies not calibrated to international standards (IU/mL).
Reference Range
Reference Range
Not Detected
Methodology
Methodology
Polymerase Chain Reaction (PCR)
CPT and LOINC
CPT and LOINC
87799 Laboratory Developed Test By Srl. LOINC: Bkv Urine Quant: 32285-9 Bvk Urine Viral Log: Not Available Bkv Urine Quant Copies: 41480-5 Bkv Urine Log Copies: 90924-2 Bkv Urine Interp: 33978-8
