Draw blood immediately before next scheduled dose. For sustained-release formulations ONLY, draw blood a minimum of 12 hours after last dose.
Collect
1.0 mL serum red top
Specimen Preparation
Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Other Acceptable Specimens
Gold top
Minimum Volumes
0.5 mL
Storage/Transport Temperature
Refrigerated
Stability (from collection to initiation)
Ambient: 28 days; Refrigerated: 28 days; Frozen: 28 days
Performed
Mon-Sun
Reported
1-2 days
Notes
Performing Lab: Mayo Clinic Laboratories
Reference Interval
10.0-40.0 mcg/mL
Interpretive Data
Most individuals display optimal response to levetiracetam with serum levels 10.0 to 40.0 mcg/mL. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; thus, interpretation should include clinical evaluation. Toxic levels have not been well established. Therapeutic ranges are based on specimen collected at trough (ie, immediately before the next dose).
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
CPT Codes
80177
Performing Lab
Mayo Clinic Laboratories
Collection
Alias
Epic: LAB1772; Mayo: LEVE
Patient Preparation
Draw blood immediately before next scheduled dose. For sustained-release formulations ONLY, draw blood a minimum of 12 hours after last dose.
Collect
1.0 mL serum red top
Specimen Preparation
Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Other Acceptable Specimens
Gold top
Minimum Volumes
0.5 mL
Storage/Transport Temperature
Refrigerated
Stability (from collection to initiation)
Ambient: 28 days; Refrigerated: 28 days; Frozen: 28 days
Performed
Mon-Sun
Reported
1-2 days
Notes
Performing Lab: Mayo Clinic Laboratories
Result Interpretation
Reference Interval
10.0-40.0 mcg/mL
Interpretive Data
Most individuals display optimal response to levetiracetam with serum levels 10.0 to 40.0 mcg/mL. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; thus, interpretation should include clinical evaluation. Toxic levels have not been well established. Therapeutic ranges are based on specimen collected at trough (ie, immediately before the next dose).
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
