Ronald Reagan UCLA Medical Center Clinical Laboratory Santa Monica UCLA Medical Center and Orthopaedic Hospital UCLA Outreach Clinical Laboratory - Panorama City (BURL)
Performing Section
Chemistry
Availability
Ronald Reagan UCLA Medical Center Clinical Laboratory and Santa Monica UCLA Medical Center and Orthopaedic Hospital:Daily, 24 hours UCLA Outreach Clinical Laboratory - Panorama City (BURL): Monday through Friday 0600 - 0230, Saturday 1200-2030 (excluding holidays)
Turnaround Time
Ronald Reagan UCLA Medical Center Clinical Laboratory and Santa Monica UCLA Medical Center and Orthopaedic Hospital: Routine: 4 hours; STAT: 1 hour from receipt in the laboratory UCLA Outreach Clinical Laboratory - Panorama City (BURL): Routine: 24 hours; STAT: 4 hours from receipt in the laboratory
Methodology
Benzethonium Chloride
Use
Evaluate proteinuria (eg, following urinalysis in which proteinuria is detected); evaluate renal diseases, including proteinuria complicating diabetes mellitus, the nephrotic syndromes, eg, lipoid nephrosis, membranous, proliferative glomerulopathies, metal poisoning (eg, gold, lead, and cadmium), renal vein thrombosis, systemic lupus erythematosus (SLE), constrictive pericarditis and amyloidosis; work up other renal diseases, including malignant hypertension, glomerulonephritis, Goodpasture's syndrome, Henoch-Schönlein purpura, thrombotic thrombocytopenic purpura, collagen diseases, cryoglobulinemia, toxemia of pregnancy, drug nephrotoxicity, hypersensitivity reactions, allergic reactions, and renal tubular lesions; manage myeloma and macroglobulinemia of Waldenström (Bence Jones proteinuria); evaluate hypoproteinemia. Tubular proteinurias include Wilson's disease and Fanconi syndrome.
See Also
LAB743 Protein/Creatinine Ratio, Random Urine
Limitations
Radiographic media and some antibiotics, especially penicillin, ampicillin, and cephalosporins, give false-positive results. Wait 48 hours before beginning urine collection. Grossly icteric samples give false-positive results and are not satisfactory.
Additional Information
Proteinuria is often the first indicator of renal disease. Glomerular diseases are the most common cause of proteinuria with serious manifestations such as the nephrotic syndrome, hypertension or progressive renal failure. Nephrotic syndrome (>3.5 g/day) can be idiopathic (membranous glomerulonephritis or minimal change disease) or due to any glomerulopathy associated with a systemic illness (eg, diabetes mellitus, SLE, amyloidosis). Tubular proteinuria is noted in patients with interstitial or tubular disorders (chronic pyelonephritis, Fanconi syndrome). Overflow proteinuria result from an increased production and hence excretion of low molecular weight proteins kappa or lambda light chains (Bence Jones protein) in myeloma, lysozyme in monocytic and monomyelocytic leukemia. Postrenal causes of proteinuria include tumors of the bladder and renal pelvis and cystitis. Proteinuria (<2 g/day) in patients with normal renal function and normal urinalysis is seen in the following three conditions: Transient proteinuria which appears following strenuous exercise or during an intercurrent illness and disappears after the primary illness has resolved (febrile illnesses, seizures, and congestive heart failure), orthostatic proteinuria which is detected only in patients when erect, none when supine (evaluated further by two 12-hour, supine and erect, urine collections for protein), and isolated proteinuria which is not affected by posture and is present throughout day (close follow-up suggested). Albumin excretion rate is a more sensitive indicator for the early detection of renal involvement in chronic diseases such as diabetes mellitus, hypertension, and SLE and more suited than total protein for therapeutic monitoring in these slowly progressive renal disorders.
Specimen Type
24-hour urine 12-hour urine acceptable
Container
24 Hour Urine Container
Collection Instructions
Obtain the collection container from Clinical Lab Support Services at (310) 267-8100 for the 24-hour urine prior to collection. Instruct the patient to void at the beginning of the collection period. Collect all urine, including the final specimen voided at the end of the 24-hour collection period. Refrigerate specimen during collection. Screw the lid on securely. Transport the specimen promptly to the Laboratory. Requisition and container(s) must be labeled with the patient's full name, hospital number, date and time collection started, and date and time collection finished.
Volume
Entire collection
Minimum Volume
5 mL aliquot
Shipping and Handling Instructions
Refrigerate
Causes for Rejection
Specimen not refrigerated during collection Specimen collected with preservative
Reference Range
0-250 mg/24 hours
Test Information
Orderable Test Codes
2331 LAB440
CPT Codes
84156 (protein, total)
Synonyms
Total Protein, Urine
Urine Protein
Performing Laboratory / Facility
Ronald Reagan UCLA Medical Center Clinical Laboratory Santa Monica UCLA Medical Center and Orthopaedic Hospital UCLA Outreach Clinical Laboratory - Panorama City (BURL)
Performing Section
Chemistry
Availability
Ronald Reagan UCLA Medical Center Clinical Laboratory and Santa Monica UCLA Medical Center and Orthopaedic Hospital:Daily, 24 hours UCLA Outreach Clinical Laboratory - Panorama City (BURL): Monday through Friday 0600 - 0230, Saturday 1200-2030 (excluding holidays)
Turnaround Time
Ronald Reagan UCLA Medical Center Clinical Laboratory and Santa Monica UCLA Medical Center and Orthopaedic Hospital: Routine: 4 hours; STAT: 1 hour from receipt in the laboratory UCLA Outreach Clinical Laboratory - Panorama City (BURL): Routine: 24 hours; STAT: 4 hours from receipt in the laboratory
Methodology
Benzethonium Chloride
Use
Evaluate proteinuria (eg, following urinalysis in which proteinuria is detected); evaluate renal diseases, including proteinuria complicating diabetes mellitus, the nephrotic syndromes, eg, lipoid nephrosis, membranous, proliferative glomerulopathies, metal poisoning (eg, gold, lead, and cadmium), renal vein thrombosis, systemic lupus erythematosus (SLE), constrictive pericarditis and amyloidosis; work up other renal diseases, including malignant hypertension, glomerulonephritis, Goodpasture's syndrome, Henoch-Schönlein purpura, thrombotic thrombocytopenic purpura, collagen diseases, cryoglobulinemia, toxemia of pregnancy, drug nephrotoxicity, hypersensitivity reactions, allergic reactions, and renal tubular lesions; manage myeloma and macroglobulinemia of Waldenström (Bence Jones proteinuria); evaluate hypoproteinemia. Tubular proteinurias include Wilson's disease and Fanconi syndrome.
See Also
LAB743 Protein/Creatinine Ratio, Random Urine
Limitations
Radiographic media and some antibiotics, especially penicillin, ampicillin, and cephalosporins, give false-positive results. Wait 48 hours before beginning urine collection. Grossly icteric samples give false-positive results and are not satisfactory.
Additional Information
Proteinuria is often the first indicator of renal disease. Glomerular diseases are the most common cause of proteinuria with serious manifestations such as the nephrotic syndrome, hypertension or progressive renal failure. Nephrotic syndrome (>3.5 g/day) can be idiopathic (membranous glomerulonephritis or minimal change disease) or due to any glomerulopathy associated with a systemic illness (eg, diabetes mellitus, SLE, amyloidosis). Tubular proteinuria is noted in patients with interstitial or tubular disorders (chronic pyelonephritis, Fanconi syndrome). Overflow proteinuria result from an increased production and hence excretion of low molecular weight proteins kappa or lambda light chains (Bence Jones protein) in myeloma, lysozyme in monocytic and monomyelocytic leukemia. Postrenal causes of proteinuria include tumors of the bladder and renal pelvis and cystitis. Proteinuria (<2 g/day) in patients with normal renal function and normal urinalysis is seen in the following three conditions: Transient proteinuria which appears following strenuous exercise or during an intercurrent illness and disappears after the primary illness has resolved (febrile illnesses, seizures, and congestive heart failure), orthostatic proteinuria which is detected only in patients when erect, none when supine (evaluated further by two 12-hour, supine and erect, urine collections for protein), and isolated proteinuria which is not affected by posture and is present throughout day (close follow-up suggested). Albumin excretion rate is a more sensitive indicator for the early detection of renal involvement in chronic diseases such as diabetes mellitus, hypertension, and SLE and more suited than total protein for therapeutic monitoring in these slowly progressive renal disorders.
Specimen Collection and Handling
Specimen Type
24-hour urine 12-hour urine acceptable
Container
24 Hour Urine Container
Collection Instructions
Obtain the collection container from Clinical Lab Support Services at (310) 267-8100 for the 24-hour urine prior to collection. Instruct the patient to void at the beginning of the collection period. Collect all urine, including the final specimen voided at the end of the 24-hour collection period. Refrigerate specimen during collection. Screw the lid on securely. Transport the specimen promptly to the Laboratory. Requisition and container(s) must be labeled with the patient's full name, hospital number, date and time collection started, and date and time collection finished.
Volume
Entire collection
Minimum Volume
5 mL aliquot
Shipping and Handling Instructions
Refrigerate
Causes for Rejection
Specimen not refrigerated during collection Specimen collected with preservative
