Performed

Twice a week

Methodology

Next Generation Sequencing (NGS)

Reported

Routine: 4 days from receipt of specimen

Synonyms

  • Myeloid Disorder NGS Panel
  • Myeloid NGS Panel
  • Myeloid Disorder Panel
  • Myeloid Panel
  • Myeloid Genomic Profile
  • Genomic Profile of Myeloid Disorders
  • Myeloid Disorders
  • Clinical Genomics

Performing Lab

Clinical Genomics

Turnaround Time

After specimen receipt in the Clinical Genomics Lab, results are generally available within 4 days.

Add-on Eligibility

Yes, within 7 days of collection
*If DNA or RNA has been extracted previously for other Clinical Genomics tests, this is stored for 6 weeks and may qualify for add-on

Specimen Type

  1. Blood
  2. Bone Marrow

Specimen Volume

Blood: 
  • Adult: 5 mL (Minimum: 1 mL)
  • Pediatric: 1 mL (Minimum: 1 mL)

Bone Marrow:
  • Adult: 3 mL (Minimum: 1 mL)
  • Pediatric: 1 mL (Minimum: 1 mL)

Collection Container

Blood: EDTA Whole Blood Tube (Lavender Top Vacutainer)


Bone Marrow: 3.0 mL EDTA Whole Blood Tube (Lavender Top Vacutainer)

Pediatric Collection

Blood: 3.0 mL EDTA Whole Blood Tube (Lavender Top Vacutainer)


Bone Marrow: 3.0 mL EDTA Whole Blood Tube (Lavender Top Vacutainer)

Unacceptable Conditions

  1. Severely clotted or grossly hemolyzed specimens
  2. Specimens that have been improperly collected, stored, or transported
  • Specimens collected in preservatives other than EDTA
    • ACD tubes are accepted, but EDTA is preferred
  • Serum or plasma
  • Specimens that have been frozen
  • Commingled specimens
  1. Specimens in tubes that have been damaged or broken during transport
  2. Specimens with insufficient volume for testing
  3. Unlabeled or mislabeled specimens

Storage/Transport Temperature

Transport Instructions
Collection Location Specimen Type Transport Temperature Timeframe
ED/
Inpatient		 Whole Blood Room Temperature Specimen must be received by the lab within 3 days of collection
Bone Marrow Room Temperature Specimen must be received by the lab within 24 hours of collection
Laboratory/
Outpatient/
Off-Site 		 Whole Blood Room Temperature Specimen must be received by the lab within 3 days of collection
Bone Marrow Room Temperature Specimen must be received by the lab within 24 hours of collection

Storage: Refrigerated

Stability (from collection to initiation)

Stability:
 
Blood:
  • Room Temperature: 3 days
  • Refrigerated: 7 days
  • Frozen: Unacceptable
 
Bone Marrow:
  • Room Temperature: 24 hours
  • Refrigerated: 7 days
  • Frozen: Unacceptable
 
Extracted DNA/RNA:
  • Room Temperature: Unacceptable
  • Refrigerated: Unacceptable
  • Frozen: Indefinitely

Laboratory Storage: 
  • Original Specimen: Refrigerated
  • Extracted DNA/RNA: Frozen
Laboratory Retention: 
  • Original Specimen: 1 month
  • Extracted DNA/RNA: 6 weeks

Collection Instructions

Labeling Instructions:
  1. When labeling blood tubes, leave a small window visible for the lab to assess the fill volume and sample integrity
  2. Ensure that the barcode is in the correct orientation.

Collection Instructions:
  1. Follow the correct order of draw when collecting with additional orders and tube types:
     

Reference Interval

By Report

Interpretive Data

This assay is designed for detection of relevant DNA mutations and fusion transcripts associated with myeloid disorders. The DNA panel is comprised of 45 key genes, while the RNA panel includes a broad fusion panel of 35 driver genes, covering the most relevant targets in major myeloid disorders, including acute myeloid leukemia (AML), myeloid dysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), and juvenile myelomonocytic leukemia (JMML).



The assay will only detect sequence variants occurring within the targeted regions. Variants outside of the targeted regions will not be detected. Mutations in genes other than those listed in the panel will not be detected.
Ordering

Performed

Twice a week

Methodology

Next Generation Sequencing (NGS)

Reported

Routine: 4 days from receipt of specimen

Synonyms

  • Myeloid Disorder NGS Panel
  • Myeloid NGS Panel
  • Myeloid Disorder Panel
  • Myeloid Panel
  • Myeloid Genomic Profile
  • Genomic Profile of Myeloid Disorders
  • Myeloid Disorders
  • Clinical Genomics

Performing Lab

Clinical Genomics

Turnaround Time

After specimen receipt in the Clinical Genomics Lab, results are generally available within 4 days.

Add-on Eligibility

Yes, within 7 days of collection
*If DNA or RNA has been extracted previously for other Clinical Genomics tests, this is stored for 6 weeks and may qualify for add-on
Collection

Specimen Type

  1. Blood
  2. Bone Marrow

Specimen Volume

Blood: 
  • Adult: 5 mL (Minimum: 1 mL)
  • Pediatric: 1 mL (Minimum: 1 mL)

Bone Marrow:
  • Adult: 3 mL (Minimum: 1 mL)
  • Pediatric: 1 mL (Minimum: 1 mL)

Collection Container

Blood: EDTA Whole Blood Tube (Lavender Top Vacutainer)


Bone Marrow: 3.0 mL EDTA Whole Blood Tube (Lavender Top Vacutainer)

Pediatric Collection

Blood: 3.0 mL EDTA Whole Blood Tube (Lavender Top Vacutainer)


Bone Marrow: 3.0 mL EDTA Whole Blood Tube (Lavender Top Vacutainer)

Unacceptable Conditions

  1. Severely clotted or grossly hemolyzed specimens
  2. Specimens that have been improperly collected, stored, or transported
  • Specimens collected in preservatives other than EDTA
    • ACD tubes are accepted, but EDTA is preferred
  • Serum or plasma
  • Specimens that have been frozen
  • Commingled specimens
  1. Specimens in tubes that have been damaged or broken during transport
  2. Specimens with insufficient volume for testing
  3. Unlabeled or mislabeled specimens

Storage/Transport Temperature

Transport Instructions
Collection Location Specimen Type Transport Temperature Timeframe
ED/
Inpatient		 Whole Blood Room Temperature Specimen must be received by the lab within 3 days of collection
Bone Marrow Room Temperature Specimen must be received by the lab within 24 hours of collection
Laboratory/
Outpatient/
Off-Site 		 Whole Blood Room Temperature Specimen must be received by the lab within 3 days of collection
Bone Marrow Room Temperature Specimen must be received by the lab within 24 hours of collection

Storage: Refrigerated

Stability (from collection to initiation)

Stability:
 
Blood:
  • Room Temperature: 3 days
  • Refrigerated: 7 days
  • Frozen: Unacceptable
 
Bone Marrow:
  • Room Temperature: 24 hours
  • Refrigerated: 7 days
  • Frozen: Unacceptable
 
Extracted DNA/RNA:
  • Room Temperature: Unacceptable
  • Refrigerated: Unacceptable
  • Frozen: Indefinitely

Laboratory Storage: 
  • Original Specimen: Refrigerated
  • Extracted DNA/RNA: Frozen
Laboratory Retention: 
  • Original Specimen: 1 month
  • Extracted DNA/RNA: 6 weeks

Collection Instructions

Labeling Instructions:
  1. When labeling blood tubes, leave a small window visible for the lab to assess the fill volume and sample integrity
  2. Ensure that the barcode is in the correct orientation.

Collection Instructions:
  1. Follow the correct order of draw when collecting with additional orders and tube types:
     
Result Interpretation

Reference Interval

By Report

Interpretive Data

This assay is designed for detection of relevant DNA mutations and fusion transcripts associated with myeloid disorders. The DNA panel is comprised of 45 key genes, while the RNA panel includes a broad fusion panel of 35 driver genes, covering the most relevant targets in major myeloid disorders, including acute myeloid leukemia (AML), myeloid dysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), and juvenile myelomonocytic leukemia (JMML).



The assay will only detect sequence variants occurring within the targeted regions. Variants outside of the targeted regions will not be detected. Mutations in genes other than those listed in the panel will not be detected.

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