UCSF Clinical Laboratories Test Directory

Available Stat

Performing Lab

Quest

Reported

Test performed Tuesday and Thursday. Turnaround time: 3-8 days.

Additional Information

Includes C1EI activity, C1EI quantitation and C1q quantitation.

The results expected of these assays in the different clinical settings in which low C4 levels are seen are:

Basis of Complement Abnormality	C1-eterase activity by C1r decay	Inhibitor Antigen Quantitation	C1q Antigen Quantitation
Hereditary angioedema-Classic	Abnormal	Decreased	Normal
Hereditary angioedema-Variant	? Abnormal	Normal	Normal
Acquired	? Abnormal	Decreased	Decreased
Secondary involvement	Normal	Normal	Normal

Synonyms

Angioedema Panel
C1-esterase inhibitor
angioneurotic edema
anti-C1r
C1r
C4DX/C4 ratio
HAE
HAN E
Hereditary angioneurotic edema

Patient Preparation

An 8 hour fast before specimen collection is preferred

Sample Type

Serum
EDTA Plasma for B&T patients

Collect

Red top on ice (Gold top NOT acceptable)
Lavender top on ice for B&T patients

Amount to Collect

6 mL blood

Preferred Volume

3 mL serum in 3 aliquots of 1 mL each

Minimum Volume

0.5 mL serum each

Remarks

Collect and allow to clot in ice slurry. Bring immediately to lab on ice.

Note special sample requirements for B&T patients.

Unacceptable Conditions

Not delivered on ice. Sample collected in Gold top

Test Code

C1EI

Sendout

Yes

Performing Lab

Quest

Specimen Preparation

Centrifuge immediately under refrigeration. Freeze three separate aliquots at <= 60C in plastic tubes and ship on dry ice. Order Quest # 44768P, 298 and 44784P

Note that LabCorp requires EDTA plasma for B&T patients.

Preferred Volume

3 mL serum in 3 aliquots of 1 mL each

Minimum Volume

0.5 mL serum each

Unacceptable Conditions

Not delivered on ice. Sample collected in Gold top

Units

see normal ranges

Reference Interval

C1EI activity (by decay of C1r):
Normal: > 67%
Equivocal: 41-67%
Abnormal: < 41%

C1EI quantitation: 11-26 mg/dL
C1q quantitation: 5.0-8.6 mg/dL

Additional Information

Includes C1EI activity, C1EI quantitation and C1q quantitation.

The results expected of these assays in the different clinical settings in which low C4 levels are seen are:

Basis of Complement Abnormality	C1-eterase activity by C1r decay	Inhibitor Antigen Quantitation	C1q Antigen Quantitation
Hereditary angioedema-Classic	Abnormal	Decreased	Normal
Hereditary angioedema-Variant	? Abnormal	Normal	Normal
Acquired	? Abnormal	Decreased	Decreased
Secondary involvement	Normal	Normal	Normal

CPT Codes

86161-90

LOINC Codes

4477-6

Available Stat

Test Code

C1EI

Performing Lab

Quest

Sendout

Yes

Patient Preparation

An 8 hour fast before specimen collection is preferred

Remarks

Collect and allow to clot in ice slurry. Bring immediately to lab on ice.

Note special sample requirements for B&T patients.

Collect

Red top on ice (Gold top NOT acceptable)
Lavender top on ice for B&T patients

Amount to Collect

6 mL blood

Sample Type

Serum
EDTA Plasma for B&T patients

Preferred Volume

3 mL serum in 3 aliquots of 1 mL each

Minimum Volume

0.5 mL serum each

Unacceptable Conditions

Not delivered on ice. Sample collected in Gold top

Specimen Preparation

Units

see normal ranges

Reference Interval

C1EI activity (by decay of C1r):
Normal: > 67%
Equivocal: 41-67%
Abnormal: < 41%

C1EI quantitation: 11-26 mg/dL
C1q quantitation: 5.0-8.6 mg/dL

Synonyms

Angioedema Panel
C1-esterase inhibitor
angioneurotic edema
anti-C1r
C1r
C4DX/C4 ratio
HAE
HAN E
Hereditary angioneurotic edema

Reported

Test performed Tuesday and Thursday. Turnaround time: 3-8 days.

Additional Information

Includes C1EI activity, C1EI quantitation and C1q quantitation.

The results expected of these assays in the different clinical settings in which low C4 levels are seen are:

Basis of Complement Abnormality	C1-eterase activity by C1r decay	Inhibitor Antigen Quantitation	C1q Antigen Quantitation
Hereditary angioedema-Classic	Abnormal	Decreased	Normal
Hereditary angioedema-Variant	? Abnormal	Normal	Normal
Acquired	? Abnormal	Decreased	Decreased
Secondary involvement	Normal	Normal	Normal

CPT Codes

86161-90

LOINC Codes

4477-6

Ordering

Available Stat

Performing Lab

Quest

Reported

Test performed Tuesday and Thursday. Turnaround time: 3-8 days.

Additional Information

Includes C1EI activity, C1EI quantitation and C1q quantitation.

The results expected of these assays in the different clinical settings in which low C4 levels are seen are:

Basis of Complement Abnormality	C1-eterase activity by C1r decay	Inhibitor Antigen Quantitation	C1q Antigen Quantitation
Hereditary angioedema-Classic	Abnormal	Decreased	Normal
Hereditary angioedema-Variant	? Abnormal	Normal	Normal
Acquired	? Abnormal	Decreased	Decreased
Secondary involvement	Normal	Normal	Normal

Synonyms

Angioedema Panel
C1-esterase inhibitor
angioneurotic edema
anti-C1r
C1r
C4DX/C4 ratio
HAE
HAN E
Hereditary angioneurotic edema

Collection

Patient Preparation

An 8 hour fast before specimen collection is preferred

Sample Type

Serum
EDTA Plasma for B&T patients

Collect

Red top on ice (Gold top NOT acceptable)
Lavender top on ice for B&T patients

Amount to Collect

6 mL blood

Preferred Volume

3 mL serum in 3 aliquots of 1 mL each

Minimum Volume

0.5 mL serum each

Remarks

Collect and allow to clot in ice slurry. Bring immediately to lab on ice.

Note special sample requirements for B&T patients.

Unacceptable Conditions

Not delivered on ice. Sample collected in Gold top

Processing

Test Code

C1EI

Sendout

Yes

Performing Lab

Quest

Specimen Preparation

Preferred Volume

3 mL serum in 3 aliquots of 1 mL each

Minimum Volume

0.5 mL serum each

Unacceptable Conditions

Not delivered on ice. Sample collected in Gold top

Result Interpretation

Units

see normal ranges

Reference Interval

C1EI activity (by decay of C1r):
Normal: > 67%
Equivocal: 41-67%
Abnormal: < 41%

C1EI quantitation: 11-26 mg/dL
C1q quantitation: 5.0-8.6 mg/dL

Additional Information

Includes C1EI activity, C1EI quantitation and C1q quantitation.

The results expected of these assays in the different clinical settings in which low C4 levels are seen are:

Basis of Complement Abnormality	C1-eterase activity by C1r decay	Inhibitor Antigen Quantitation	C1q Antigen Quantitation
Hereditary angioedema-Classic	Abnormal	Decreased	Normal
Hereditary angioedema-Variant	? Abnormal	Normal	Normal
Acquired	? Abnormal	Decreased	Decreased
Secondary involvement	Normal	Normal	Normal

Administrative

CPT Codes

86161-90

LOINC Codes

4477-6

Complete View

Available Stat

Test Code

C1EI

Performing Lab

Quest

Sendout

Yes

Patient Preparation

An 8 hour fast before specimen collection is preferred

Remarks

Collect and allow to clot in ice slurry. Bring immediately to lab on ice.

Note special sample requirements for B&T patients.

Collect

Red top on ice (Gold top NOT acceptable)
Lavender top on ice for B&T patients

Amount to Collect

6 mL blood

Sample Type

Serum
EDTA Plasma for B&T patients

Preferred Volume

3 mL serum in 3 aliquots of 1 mL each

Minimum Volume

0.5 mL serum each

Unacceptable Conditions

Not delivered on ice. Sample collected in Gold top

Specimen Preparation

Units

see normal ranges

Reference Interval

C1EI activity (by decay of C1r):
Normal: > 67%
Equivocal: 41-67%
Abnormal: < 41%

C1EI quantitation: 11-26 mg/dL
C1q quantitation: 5.0-8.6 mg/dL

Synonyms

Angioedema Panel
C1-esterase inhibitor
angioneurotic edema
anti-C1r
C1r
C4DX/C4 ratio
HAE
HAN E
Hereditary angioneurotic edema

Reported

Test performed Tuesday and Thursday. Turnaround time: 3-8 days.

Additional Information

Includes C1EI activity, C1EI quantitation and C1q quantitation.

The results expected of these assays in the different clinical settings in which low C4 levels are seen are:

Basis of Complement Abnormality	C1-eterase activity by C1r decay	Inhibitor Antigen Quantitation	C1q Antigen Quantitation
Hereditary angioedema-Classic	Abnormal	Decreased	Normal
Hereditary angioedema-Variant	? Abnormal	Normal	Normal
Acquired	? Abnormal	Decreased	Decreased
Secondary involvement	Normal	Normal	Normal

CPT Codes

86161-90

LOINC Codes

4477-6