Available Stat

No

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Methodology

GDA SNP Array

Reported

3-21 days

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds)
Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

The lab will charge a tissue culture setup fees (TCAFCV) if SNP microarray is ordered without chromosomes studies

Synonyms

  • SNP array amniocentesis
  • SNP array CVS
  • SNP array chorionic villus sample

Sample Type

Amniotic fluid or chorionic villi only

Cytogenetics laboratory only accepts genomic DNA samples for clinical microarray testing when they are extracted in a CLIA-certified laboratory and meet the lab requirement, including >=500 ng DNA with a concentration >=50ng/uL and A260/280 ratio >=1.8. Electrophoresis gel image and/or DNA integrity related information should also be provided to the lab. Acceptance of any extracted gDNA sample should be approved by the lab director. Contact Cytogenetics 514-8964. 

Collect

Sterile centrifuge tube, CVS in transport media provided by lab

Amount to Collect

See preferred volume.

Preferred Volume

Direct Array ONLY:
Amniotic fluid 25 mL non-bloody fluid (20 mL for array 5 mL for backup)
Placental Villi 20-25 mg
Cultured cells 2 confluent T25 flasks


Chromosome analysis with reflex to array if normal
Amniotic fluid 30 mL non-bloody fluid
Placental Villi 30 mg


Additional fluid or villi may be needed if additional tests are ordered

Aneuvysion FISH add 5 mL amniotic fluid or 5 mg villi.

Minimum Volume

Amniotic fluid 20 mL
Villi 20 mg


These minimum amounts may limit testing that can be performed

Remarks

Insurance pre-authorization required for outpatients

Do not collect sample in lithium heparin (Lt. Green top).

Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.

Stability (from collection to initiation)

24 hours at Room temperature

Unacceptable Conditions

Leaking, contaminated, frozen or mislabeled tube(s)

Test Code

SNPAP

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Specimen Preparation

Refrigerate samples DO NOT CENTRIFUGE OR FREEZE. Transport asap to China Basin Cytogenetics

For questions, contact the microarray laboratory at 514-8964

Preferred Volume

Direct Array ONLY:
Amniotic fluid 25 mL non-bloody fluid (20 mL for array 5 mL for backup)
Placental Villi 20-25 mg
Cultured cells 2 confluent T25 flasks


Chromosome analysis with reflex to array if normal
Amniotic fluid 30 mL non-bloody fluid
Placental Villi 30 mg


Additional fluid or villi may be needed if additional tests are ordered

Aneuvysion FISH add 5 mL amniotic fluid or 5 mg villi.

Minimum Volume

Amniotic fluid 20 mL
Villi 20 mg


These minimum amounts may limit testing that can be performed

Unacceptable Conditions

Leaking, contaminated, frozen or mislabeled tube(s)

Stability (from collection to initiation)

24 hours at Room temperature

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds)
Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

The lab will charge a tissue culture setup fees (TCAFCV) if SNP microarray is ordered without chromosomes studies

CPT Codes

81229, 88233

Note: Additional charges for MCC studies when necessary, culture set-up fees may apply.

LDT or Modified FDA

Yes

Available Stat

No

Test Code

SNPAP

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Methodology

GDA SNP Array

Remarks

Insurance pre-authorization required for outpatients

Do not collect sample in lithium heparin (Lt. Green top).

Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.

Collect

Sterile centrifuge tube, CVS in transport media provided by lab

Amount to Collect

See preferred volume.

Sample Type

Amniotic fluid or chorionic villi only

Cytogenetics laboratory only accepts genomic DNA samples for clinical microarray testing when they are extracted in a CLIA-certified laboratory and meet the lab requirement, including >=500 ng DNA with a concentration >=50ng/uL and A260/280 ratio >=1.8. Electrophoresis gel image and/or DNA integrity related information should also be provided to the lab. Acceptance of any extracted gDNA sample should be approved by the lab director. Contact Cytogenetics 514-8964. 

Preferred Volume

Direct Array ONLY:
Amniotic fluid 25 mL non-bloody fluid (20 mL for array 5 mL for backup)
Placental Villi 20-25 mg
Cultured cells 2 confluent T25 flasks


Chromosome analysis with reflex to array if normal
Amniotic fluid 30 mL non-bloody fluid
Placental Villi 30 mg


Additional fluid or villi may be needed if additional tests are ordered

Aneuvysion FISH add 5 mL amniotic fluid or 5 mg villi.

Minimum Volume

Amniotic fluid 20 mL
Villi 20 mg


These minimum amounts may limit testing that can be performed

Unacceptable Conditions

Leaking, contaminated, frozen or mislabeled tube(s)

Specimen Preparation

Refrigerate samples DO NOT CENTRIFUGE OR FREEZE. Transport asap to China Basin Cytogenetics

For questions, contact the microarray laboratory at 514-8964

Synonyms

  • SNP array amniocentesis
  • SNP array CVS
  • SNP array chorionic villus sample

Stability (from collection to initiation)

24 hours at Room temperature

Reported

3-21 days

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds)
Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

The lab will charge a tissue culture setup fees (TCAFCV) if SNP microarray is ordered without chromosomes studies

CPT Codes

81229, 88233

Note: Additional charges for MCC studies when necessary, culture set-up fees may apply.

LDT or Modified FDA

Yes
Ordering

Available Stat

No

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Methodology

GDA SNP Array

Reported

3-21 days

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds)
Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

The lab will charge a tissue culture setup fees (TCAFCV) if SNP microarray is ordered without chromosomes studies

Synonyms

  • SNP array amniocentesis
  • SNP array CVS
  • SNP array chorionic villus sample
Collection

Sample Type

Amniotic fluid or chorionic villi only

Cytogenetics laboratory only accepts genomic DNA samples for clinical microarray testing when they are extracted in a CLIA-certified laboratory and meet the lab requirement, including >=500 ng DNA with a concentration >=50ng/uL and A260/280 ratio >=1.8. Electrophoresis gel image and/or DNA integrity related information should also be provided to the lab. Acceptance of any extracted gDNA sample should be approved by the lab director. Contact Cytogenetics 514-8964. 

Collect

Sterile centrifuge tube, CVS in transport media provided by lab

Amount to Collect

See preferred volume.

Preferred Volume

Direct Array ONLY:
Amniotic fluid 25 mL non-bloody fluid (20 mL for array 5 mL for backup)
Placental Villi 20-25 mg
Cultured cells 2 confluent T25 flasks


Chromosome analysis with reflex to array if normal
Amniotic fluid 30 mL non-bloody fluid
Placental Villi 30 mg


Additional fluid or villi may be needed if additional tests are ordered

Aneuvysion FISH add 5 mL amniotic fluid or 5 mg villi.

Minimum Volume

Amniotic fluid 20 mL
Villi 20 mg


These minimum amounts may limit testing that can be performed

Remarks

Insurance pre-authorization required for outpatients

Do not collect sample in lithium heparin (Lt. Green top).

Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.

Stability (from collection to initiation)

24 hours at Room temperature

Unacceptable Conditions

Leaking, contaminated, frozen or mislabeled tube(s)
Processing

Test Code

SNPAP

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Specimen Preparation

Refrigerate samples DO NOT CENTRIFUGE OR FREEZE. Transport asap to China Basin Cytogenetics

For questions, contact the microarray laboratory at 514-8964

Preferred Volume

Direct Array ONLY:
Amniotic fluid 25 mL non-bloody fluid (20 mL for array 5 mL for backup)
Placental Villi 20-25 mg
Cultured cells 2 confluent T25 flasks


Chromosome analysis with reflex to array if normal
Amniotic fluid 30 mL non-bloody fluid
Placental Villi 30 mg


Additional fluid or villi may be needed if additional tests are ordered

Aneuvysion FISH add 5 mL amniotic fluid or 5 mg villi.

Minimum Volume

Amniotic fluid 20 mL
Villi 20 mg


These minimum amounts may limit testing that can be performed

Unacceptable Conditions

Leaking, contaminated, frozen or mislabeled tube(s)

Stability (from collection to initiation)

24 hours at Room temperature
Result Interpretation

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds)
Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

The lab will charge a tissue culture setup fees (TCAFCV) if SNP microarray is ordered without chromosomes studies
Administrative

CPT Codes

81229, 88233

Note: Additional charges for MCC studies when necessary, culture set-up fees may apply.

LDT or Modified FDA

Yes
Complete View

Available Stat

No

Test Code

SNPAP

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Methodology

GDA SNP Array

Remarks

Insurance pre-authorization required for outpatients

Do not collect sample in lithium heparin (Lt. Green top).

Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.

Collect

Sterile centrifuge tube, CVS in transport media provided by lab

Amount to Collect

See preferred volume.

Sample Type

Amniotic fluid or chorionic villi only

Cytogenetics laboratory only accepts genomic DNA samples for clinical microarray testing when they are extracted in a CLIA-certified laboratory and meet the lab requirement, including >=500 ng DNA with a concentration >=50ng/uL and A260/280 ratio >=1.8. Electrophoresis gel image and/or DNA integrity related information should also be provided to the lab. Acceptance of any extracted gDNA sample should be approved by the lab director. Contact Cytogenetics 514-8964. 

Preferred Volume

Direct Array ONLY:
Amniotic fluid 25 mL non-bloody fluid (20 mL for array 5 mL for backup)
Placental Villi 20-25 mg
Cultured cells 2 confluent T25 flasks


Chromosome analysis with reflex to array if normal
Amniotic fluid 30 mL non-bloody fluid
Placental Villi 30 mg


Additional fluid or villi may be needed if additional tests are ordered

Aneuvysion FISH add 5 mL amniotic fluid or 5 mg villi.

Minimum Volume

Amniotic fluid 20 mL
Villi 20 mg


These minimum amounts may limit testing that can be performed

Unacceptable Conditions

Leaking, contaminated, frozen or mislabeled tube(s)

Specimen Preparation

Refrigerate samples DO NOT CENTRIFUGE OR FREEZE. Transport asap to China Basin Cytogenetics

For questions, contact the microarray laboratory at 514-8964

Synonyms

  • SNP array amniocentesis
  • SNP array CVS
  • SNP array chorionic villus sample

Stability (from collection to initiation)

24 hours at Room temperature

Reported

3-21 days

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds)
Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

The lab will charge a tissue culture setup fees (TCAFCV) if SNP microarray is ordered without chromosomes studies

CPT Codes

81229, 88233

Note: Additional charges for MCC studies when necessary, culture set-up fees may apply.

LDT or Modified FDA

Yes

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