Approval Required

Yes, if not ordered by Genetics, Neurology or Neonatal Intensive Care Unit faculty or fellows. Requests on inpatients require approval from Cytogenetics/Array staff. Insurance authorization required.

Available Stat

No

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Methodology

850K SNP array

Reported

10-21 days

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds) Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

Synonyms

  • Parental SNP Array

Sample Type

EDTA or Heparinized whole blood, Extracted DNA

Cytogenetics laboratory only accepts genomic DNA samples for clinical microarray testing when they are extracted in a CLIA-certified laboratory and meet the lab requirement, including >=500 ng DNA with a concentration >=50ng/uL and A260/280 ratio >=1.8. Electrophoresis gel image and/or DNA integrity related information should also be provided to the lab. Acceptance of any extracted gDNA sample should be approved by the lab director. Contact Cytogenetics 514-8964. 

Collect

Lavender top preferred, Dark green top acceptable

Amount to Collect

See preferred volume

Preferred Volume

Adult 5 mL whole blood
Infant/Child 3 mL whole blood
Extracted DNA 10 µg (mcg)

Minimum Volume

Adult 2 mL whole blood
Infant/Child 2 mL whole blood
Extracted DNA 10 µg (mcg)

Remarks

Insurance pre-authorization required for outpatients

Only collect samples Monday - Friday and avoid holidays.

Do not collect sample in lithium heparin (Lt. Green top).

Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.

Stability (from collection to initiation)

Room temperature 4 days, refrigerated 2 weeks

Test Code

PSNPA

Test Group

Microarray

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Specimen Preparation

Refrigerate samples DO NOT CENTRIFUGE OR FREEZE. Transport asap to China Basin Cytogenetics

For questions, contact the microarray laboratory at 514-8964

Preferred Volume

Adult 5 mL whole blood
Infant/Child 3 mL whole blood
Extracted DNA 10 µg (mcg)

Minimum Volume

Adult 2 mL whole blood
Infant/Child 2 mL whole blood
Extracted DNA 10 µg (mcg)

Stability (from collection to initiation)

Room temperature 4 days, refrigerated 2 weeks

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds) Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

CPT Codes

81229

LDT or Modified FDA

Yes

LOINC Codes

62375-1

Approval Required

Yes, if not ordered by Genetics, Neurology or Neonatal Intensive Care Unit faculty or fellows. Requests on inpatients require approval from Cytogenetics/Array staff. Insurance authorization required.

Available Stat

No

Test Code

PSNPA

Test Group

Microarray

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Methodology

850K SNP array

Remarks

Insurance pre-authorization required for outpatients

Only collect samples Monday - Friday and avoid holidays.

Do not collect sample in lithium heparin (Lt. Green top).

Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.

Collect

Lavender top preferred, Dark green top acceptable

Amount to Collect

See preferred volume

Sample Type

EDTA or Heparinized whole blood, Extracted DNA

Cytogenetics laboratory only accepts genomic DNA samples for clinical microarray testing when they are extracted in a CLIA-certified laboratory and meet the lab requirement, including >=500 ng DNA with a concentration >=50ng/uL and A260/280 ratio >=1.8. Electrophoresis gel image and/or DNA integrity related information should also be provided to the lab. Acceptance of any extracted gDNA sample should be approved by the lab director. Contact Cytogenetics 514-8964. 

Preferred Volume

Adult 5 mL whole blood
Infant/Child 3 mL whole blood
Extracted DNA 10 µg (mcg)

Minimum Volume

Adult 2 mL whole blood
Infant/Child 2 mL whole blood
Extracted DNA 10 µg (mcg)

Specimen Preparation

Refrigerate samples DO NOT CENTRIFUGE OR FREEZE. Transport asap to China Basin Cytogenetics

For questions, contact the microarray laboratory at 514-8964

Synonyms

  • Parental SNP Array

Stability (from collection to initiation)

Room temperature 4 days, refrigerated 2 weeks

Reported

10-21 days

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds) Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

CPT Codes

81229

LDT or Modified FDA

Yes

LOINC Codes

62375-1
Ordering

Approval Required

Yes, if not ordered by Genetics, Neurology or Neonatal Intensive Care Unit faculty or fellows. Requests on inpatients require approval from Cytogenetics/Array staff. Insurance authorization required.

Available Stat

No

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Methodology

850K SNP array

Reported

10-21 days

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds) Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

Synonyms

  • Parental SNP Array
Collection

Sample Type

EDTA or Heparinized whole blood, Extracted DNA

Cytogenetics laboratory only accepts genomic DNA samples for clinical microarray testing when they are extracted in a CLIA-certified laboratory and meet the lab requirement, including >=500 ng DNA with a concentration >=50ng/uL and A260/280 ratio >=1.8. Electrophoresis gel image and/or DNA integrity related information should also be provided to the lab. Acceptance of any extracted gDNA sample should be approved by the lab director. Contact Cytogenetics 514-8964. 

Collect

Lavender top preferred, Dark green top acceptable

Amount to Collect

See preferred volume

Preferred Volume

Adult 5 mL whole blood
Infant/Child 3 mL whole blood
Extracted DNA 10 µg (mcg)

Minimum Volume

Adult 2 mL whole blood
Infant/Child 2 mL whole blood
Extracted DNA 10 µg (mcg)

Remarks

Insurance pre-authorization required for outpatients

Only collect samples Monday - Friday and avoid holidays.

Do not collect sample in lithium heparin (Lt. Green top).

Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.

Stability (from collection to initiation)

Room temperature 4 days, refrigerated 2 weeks
Processing

Test Code

PSNPA

Test Group

Microarray

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Specimen Preparation

Refrigerate samples DO NOT CENTRIFUGE OR FREEZE. Transport asap to China Basin Cytogenetics

For questions, contact the microarray laboratory at 514-8964

Preferred Volume

Adult 5 mL whole blood
Infant/Child 3 mL whole blood
Extracted DNA 10 µg (mcg)

Minimum Volume

Adult 2 mL whole blood
Infant/Child 2 mL whole blood
Extracted DNA 10 µg (mcg)

Stability (from collection to initiation)

Room temperature 4 days, refrigerated 2 weeks
Result Interpretation

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds) Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)
Administrative

CPT Codes

81229

LDT or Modified FDA

Yes

LOINC Codes

62375-1
Complete View

Approval Required

Yes, if not ordered by Genetics, Neurology or Neonatal Intensive Care Unit faculty or fellows. Requests on inpatients require approval from Cytogenetics/Array staff. Insurance authorization required.

Available Stat

No

Test Code

PSNPA

Test Group

Microarray

Performing Lab

Medical Genomics - Cytogenetics (Microarray)

Methodology

850K SNP array

Remarks

Insurance pre-authorization required for outpatients

Only collect samples Monday - Friday and avoid holidays.

Do not collect sample in lithium heparin (Lt. Green top).

Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.

Collect

Lavender top preferred, Dark green top acceptable

Amount to Collect

See preferred volume

Sample Type

EDTA or Heparinized whole blood, Extracted DNA

Cytogenetics laboratory only accepts genomic DNA samples for clinical microarray testing when they are extracted in a CLIA-certified laboratory and meet the lab requirement, including >=500 ng DNA with a concentration >=50ng/uL and A260/280 ratio >=1.8. Electrophoresis gel image and/or DNA integrity related information should also be provided to the lab. Acceptance of any extracted gDNA sample should be approved by the lab director. Contact Cytogenetics 514-8964. 

Preferred Volume

Adult 5 mL whole blood
Infant/Child 3 mL whole blood
Extracted DNA 10 µg (mcg)

Minimum Volume

Adult 2 mL whole blood
Infant/Child 2 mL whole blood
Extracted DNA 10 µg (mcg)

Specimen Preparation

Refrigerate samples DO NOT CENTRIFUGE OR FREEZE. Transport asap to China Basin Cytogenetics

For questions, contact the microarray laboratory at 514-8964

Synonyms

  • Parental SNP Array

Stability (from collection to initiation)

Room temperature 4 days, refrigerated 2 weeks

Reported

10-21 days

Additional Information

Limitations
Genomic aberrations that may not be detected by SNP array assay include:
- Balanced rearrangement (i.e. balanced translocation, insertion or inversion) and tetraploidy resulted from endoduplication.
- Low level (<30%) mosaicism for unbalanced rearrangements and aneuploidy
- Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection or cut-off thresholds) Imbalances of regions not represented on the array
- Genomic changes in mixed samples (i.e. prenatal samples with maternal cell contamination)

CPT Codes

81229

LDT or Modified FDA

Yes

LOINC Codes

62375-1

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