Use this code if a patient presents without a kit or if ordered on an inpatient who does not have their own kit.
As of November 2013, order this if transplant patient has no kit. Fax results to UW.
Trough levels should be drawn.
Reference Interval
Effective November 17, 2014
Therapeutic Range:
Cyclosporine A, Therapeutic Range
100-400 ng/mL
Kidney transplant (in combination with Everolimus)
Up to 3 months post-transplant: 350-525 ng/mL 4 months and older post-transplant: 145-350 ng/mL
Liver transplant
290-525 ng/mL
Toxic value
Greater than 700 ng/mL
Interpretive Data
The general therapeutic range for cyclosporine A is 100-400 ng/mL. The optimal therapeutic range for a given patient may differ from this suggested range based on the indication for therapy, treatment phase (initiation or maintenance), use in combination with other drugs, time of specimen collection relative to prior dose, type of transplanted organ, and/or the therapeutic approach of the transplant center.
Notes
Cyclosporine (Sandimmune) whole blood concentrations can be measured by either chromatographic or immunoassay methodologies. These two methodologies are not directly interchangeable, and the measured cyclosporine whole blood concentration depends on the methodology used. Reference ranges may vary according to the specific immunoassay or HPLC-MS/MS test. Generally, immunoassays have been reported to have a positive bias relative to HPLC-MS/MS assays due to the detection of antibody cross-reactivity with cyclosporine metabolites.
CPT Codes
80158
Billable SIM Number(s)
3018015801
LOINC
3520-4
Overview
Ordering Recommendations
Use to optimize dosing and monitor patient adherence.
Orderable SIM Number(s)
CYCLOSPORINE LEVEL (LAB874)
Synonyms
Neoral
Sandimmune
Cyclosporine
Gengraf
Restasis
LAB874
ARUP Test Code
0070035
Specimen
Patient Preparation
Predose (trough) levels should be drawn.
Collect
Lavender (EDTA) or pink (K2EDTA).
Specimen Preparation
Transport 1 mL whole blood. (Min: 0.25 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Serum or plasma. Specimens left at room temperature for longer than 24 hours. Clotted specimens.
Use this code if a patient presents without a kit or if ordered on an inpatient who does not have their own kit.
As of November 2013, order this if transplant patient has no kit. Fax results to UW.
Trough levels should be drawn.
Interpretive
Reference Interval
Effective November 17, 2014
Therapeutic Range:
Cyclosporine A, Therapeutic Range
100-400 ng/mL
Kidney transplant (in combination with Everolimus)
Up to 3 months post-transplant: 350-525 ng/mL 4 months and older post-transplant: 145-350 ng/mL
Liver transplant
290-525 ng/mL
Toxic value
Greater than 700 ng/mL
Interpretive Data
The general therapeutic range for cyclosporine A is 100-400 ng/mL. The optimal therapeutic range for a given patient may differ from this suggested range based on the indication for therapy, treatment phase (initiation or maintenance), use in combination with other drugs, time of specimen collection relative to prior dose, type of transplanted organ, and/or the therapeutic approach of the transplant center.
Notes
Cyclosporine (Sandimmune) whole blood concentrations can be measured by either chromatographic or immunoassay methodologies. These two methodologies are not directly interchangeable, and the measured cyclosporine whole blood concentration depends on the methodology used. Reference ranges may vary according to the specific immunoassay or HPLC-MS/MS test. Generally, immunoassays have been reported to have a positive bias relative to HPLC-MS/MS assays due to the detection of antibody cross-reactivity with cyclosporine metabolites.
Coding
CPT Codes
80158
Billable SIM Number(s)
3018015801
LOINC
3520-4
Performed
Performed
Sun-Sat
Reported/Turnaround Time
Reported
2-4 days
Methodology
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
