Recommended test for the surveillance of residual/recurrent thyroid cancer. Accurately measures thyroglobulin levels in serum or plasma.
Test Mnemonic
THYROG
Collect
Serum separator tube (SST). Also acceptable: Green (sodium or lithium heparin).
Specimen Preparation
Transfer 3 mL serum or plasma to an ARUP standard transport tube. (Min: 1.5 mL)
Storage/Transport Temperature
Frozen.
Stability (from collection to initiation)
After separation from cells: Ambient: 8 hours; Refrigerated: 1 week; Frozen: 6 months
Unacceptable Conditions
EDTA or K2EDTA plasma. Grossly lipemic samples. Any fluid other than noted above. (See Thyroglobulin, Fine Needle Aspiration (FNA) (ARUP test code 0020753) for ordering alternate fluids).
Notes
The reflex testing method (CIA or LC-MS/MS) is determined by the TgAb result. Additional charges apply.
Quantitative Chemiluminescent Immunoassay (CLIA) / High Performance Liquid Chromatography-Tandem Mass Spectrometry
Reference Interval
Components
Reference Interval
Thyroglobulin Antibody
0.0-4.0 IU/mL
Thyroglobulin, Serum or Plasma
Age
ng/mL
6 months - 3 years
7.4-48.7
4-7 years
4.1-40.5
8-17 years
0.8-29.4
18 years and older
1.3-31.8
Thyroglobulin by LC-MS/MS, Serum/Plasma
Age
ng/mL
6 months - 3 years
7.4-48.7
4-7 years
4.1-40.5
8-17 years
0.8-29.4
18 years and older
1.3-31.8
Interpretive Data
Specimens negative for thyroglobulin antibodies (TgAb) are tested for thyroglobulin (Tg) by chemiluminescent immunoassay (CIA) using the Beckman Coulter Access DxI method. Specimens with TgAb results above the upper reference limit are tested for Tg by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results obtained with different test methods or kits cannot be used interchangeably. Tg results, regardless of concentration, should not be interpreted as absolute evidence for the presence or absence of papillary or follicular thyroid cancer. Tg testing is not recommended for use as a screening procedure to detect the presence of thyroid cancer in the general population.
Lower limit of detection for thyroglobulin by LC-MS/MS is 0.5 ng/mL.
Ordering / Collection
Ordering Recommendations
Recommended test for the surveillance of residual/recurrent thyroid cancer. Accurately measures thyroglobulin levels in serum or plasma.
Test Mnemonic
THYROG
Collect
Serum separator tube (SST). Also acceptable: Green (sodium or lithium heparin).
Specimen Preparation
Transfer 3 mL serum or plasma to an ARUP standard transport tube. (Min: 1.5 mL)
Storage/Transport Temperature
Frozen.
Stability (from collection to initiation)
After separation from cells: Ambient: 8 hours; Refrigerated: 1 week; Frozen: 6 months
Unacceptable Conditions
EDTA or K2EDTA plasma. Grossly lipemic samples. Any fluid other than noted above. (See Thyroglobulin, Fine Needle Aspiration (FNA) (ARUP test code 0020753) for ordering alternate fluids).
Notes
The reflex testing method (CIA or LC-MS/MS) is determined by the TgAb result. Additional charges apply.
Quantitative Chemiluminescent Immunoassay (CLIA) / High Performance Liquid Chromatography-Tandem Mass Spectrometry
Clinical Information
Reference Interval
Components
Reference Interval
Thyroglobulin Antibody
0.0-4.0 IU/mL
Thyroglobulin, Serum or Plasma
Age
ng/mL
6 months - 3 years
7.4-48.7
4-7 years
4.1-40.5
8-17 years
0.8-29.4
18 years and older
1.3-31.8
Thyroglobulin by LC-MS/MS, Serum/Plasma
Age
ng/mL
6 months - 3 years
7.4-48.7
4-7 years
4.1-40.5
8-17 years
0.8-29.4
18 years and older
1.3-31.8
Interpretive Data
Specimens negative for thyroglobulin antibodies (TgAb) are tested for thyroglobulin (Tg) by chemiluminescent immunoassay (CIA) using the Beckman Coulter Access DxI method. Specimens with TgAb results above the upper reference limit are tested for Tg by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results obtained with different test methods or kits cannot be used interchangeably. Tg results, regardless of concentration, should not be interpreted as absolute evidence for the presence or absence of papillary or follicular thyroid cancer. Tg testing is not recommended for use as a screening procedure to detect the presence of thyroid cancer in the general population.
Lower limit of detection for thyroglobulin by LC-MS/MS is 0.5 ng/mL.
Laboratories.