Collect

Constitutional SNP: Blood in 4mL DkGr NaHep AND 3mL Lav EDTA. (2 tubes needed)

Prenatal SNP: AmnioFluid or CVS (plus parental samples 2 tubes) in Sterile Cont (AF & CVS); Parental: 4mL DkGr NaHep AND 3mL Lav EDTA.

Oncology SNP: Blood or Bone Marrow in 4mL DkGr NaHep AND 3mL Lav EDTA.

Minimum Collection Volume

A total of 2 tubes is needed for Constitutional or Oncology Microarray; 3-4 mL of whole bone marrow or oncology blood or peripheral blood in Dark Green top Sodium Heparin tube AND 3-4 mL of whole bone marrow or oncology blood or peripheral blood in a Lavender top EDTA tube. 

FOR PRENATAL Microarray:  2 mL of whole amniotic fluid or 30-100 mg of chorionic villi (for PRENATAL microarray)

If a lesser volume of sample listed above is sent, the laboratory will attempt to perform the test requested.  The laboratory cannot assure either a result and/or the ability to perform repeat testing and/or additional testing if the minimum volumes are not met.

Acceptable Specimen Collect Alternatives

ACD (Yellow) top blood tube is acceptable.

SALIVA that is collected in the Oragene collection kit is also an acceptable alternative specimen type. 
      Oragene Saliva Kit Order Information: available free by request: call - 513-636-4474

If DNA is sent, it MUST have been extracted in a CLIA certified laboratory.

Shipping/Handling Instructions (Lab Use Only)

Room Temperature. Do NOT spin. Burnet: Call GENETICS (6-4474) immediately upon arrival.

External Client Shipping and Handling

Store at room temperature  / Use overnight shipping (protect from temperature extremes, no ice). or call the lab for local courier service (contact laboratory prior to drawing specimen to ensure courier area coverage).  Do NOT spin tubes.

Stability (from collection to initiation)

SEND TO GENETICS to determine viability of specimen; Call the Genetics Lab at 513-636-4474 for pick up or for any questions or concerns about the specimen.

Notes

For Constitutional Microarray SNP:  a total of 2 tubes needed; 3-4 mL of whole peripheral blood in Dark Green top Sodium Heparin tube AND 3-4 mL of whole peripheral blood in a Lavender top EDTA tube. 

For Prenatal Microarray SNP: 2 mL of whole amniotic fluid or 30-100 mg of chorionic villi in sterile transport medium - send parental samples also (a total of 2 tubes needed on EACH parent; 3-4 mL of whole peripheral blood in Dark Green top Sodium Heparin tube AND 3-4 mL of whole peripheral blood in a Lavender top EDTA tube)

For Oncology Microarray SNP:   a total of 2 tubes needed; 3-4 mL of whole bone marrow or oncology blood in Dark Green top Sodium Heparin tube AND 3-4 mL of whole bone marrow or oncology blood in a Lavender top EDTA tube. The lab should be able to perform both Oncology FISH and Oncology Chromosome Analysis in addition to the Oncology Microarray SNP with the above sample requirements - so NO additional specimen is needed for those studies if the required 2 tubes are sent.

Collection personnel MUST initial specimen container to confirm sample identity. Label tubes with patient name and date of birth (DOB).


Pediatric Collection

Prenatal:  For twin pregnancies, label tubes with the mother's name and "TWIN A" on one fetal sample and "TWIN B" on the second fetal sample.

Performing Lab

Cytogenetics Laboratory 
Phone: (513) 636-4474
Fax: (513) 636-4414

Hours: Dayshift (Monday through Friday)

Remarks

Cincinnati Children's is an Illumina Certified Service Provider (CSPro).

Cincinnati Children’s Cytogenetics Laboratory is a CAP-accredited CLIA-certified clinical laboratory offering Microarray services to detect DNA copy number changes. Our knowledgeable and experienced team provides two service options for multiple sample types:

Tech Only with data generation or Full Service with data generation and comprehensive cytogenetic copy number data interpretation

Synonyms

  • AMNIOTIC FLUID SNP MICROARRAY
  • PRENATAL MICROARRAY : SNP
  • SNP MICROARRAY
  • CHORIONIC VILLI (CVS) SNP MICROARRAY
  • CYTOGENETIC MICROARRAY
  • ONCOLOGY SNP MICROARRAY
  • 253 - MICROARRAY : SNP
  • Constitutional Microarray : SNP
  • MA SNP

Reflex Testing

If the MICROARRAY : SNP sample is for PRENATAL STUDIES (from amniotic fluid or chorionic villi), there will be an additional charge added for culture of the sample (CPT code 88240).

Methodology

Microarray analysis is performed using a SNP based microarray chip with over approximately 840,000 markers. This test is designed to identify chromosomal imbalances throughout the human genome including deletions, duplications, aneuploidy, and region of homozygosity. Our laboratory has established criteria for reporting abnormalities based on size, gene content, and clinical significance.

Reported

3 Weeks

CPT Codes

FOR Constitutional MA SNP:  81229
FOR Oncology MA SNP:  81277
PRENATAL SNP needing Tissue CULTURE:  add 88240 to Constitutional MA : SNP


Please call 1-866-450-4198 for pricing or with any billing questions.

Collection

Collect

Constitutional SNP: Blood in 4mL DkGr NaHep AND 3mL Lav EDTA. (2 tubes needed)

Prenatal SNP: AmnioFluid or CVS (plus parental samples 2 tubes) in Sterile Cont (AF & CVS); Parental: 4mL DkGr NaHep AND 3mL Lav EDTA.

Oncology SNP: Blood or Bone Marrow in 4mL DkGr NaHep AND 3mL Lav EDTA.

Minimum Collection Volume

A total of 2 tubes is needed for Constitutional or Oncology Microarray; 3-4 mL of whole bone marrow or oncology blood or peripheral blood in Dark Green top Sodium Heparin tube AND 3-4 mL of whole bone marrow or oncology blood or peripheral blood in a Lavender top EDTA tube. 

FOR PRENATAL Microarray:  2 mL of whole amniotic fluid or 30-100 mg of chorionic villi (for PRENATAL microarray)

If a lesser volume of sample listed above is sent, the laboratory will attempt to perform the test requested.  The laboratory cannot assure either a result and/or the ability to perform repeat testing and/or additional testing if the minimum volumes are not met.

Acceptable Specimen Collect Alternatives

ACD (Yellow) top blood tube is acceptable.

SALIVA that is collected in the Oragene collection kit is also an acceptable alternative specimen type. 
      Oragene Saliva Kit Order Information: available free by request: call - 513-636-4474

If DNA is sent, it MUST have been extracted in a CLIA certified laboratory.

Shipping/Handling Instructions (Lab Use Only)

Room Temperature. Do NOT spin. Burnet: Call GENETICS (6-4474) immediately upon arrival.

External Client Shipping and Handling

Store at room temperature  / Use overnight shipping (protect from temperature extremes, no ice). or call the lab for local courier service (contact laboratory prior to drawing specimen to ensure courier area coverage).  Do NOT spin tubes.

Stability (from collection to initiation)

SEND TO GENETICS to determine viability of specimen; Call the Genetics Lab at 513-636-4474 for pick up or for any questions or concerns about the specimen.

Notes

For Constitutional Microarray SNP:  a total of 2 tubes needed; 3-4 mL of whole peripheral blood in Dark Green top Sodium Heparin tube AND 3-4 mL of whole peripheral blood in a Lavender top EDTA tube. 

For Prenatal Microarray SNP: 2 mL of whole amniotic fluid or 30-100 mg of chorionic villi in sterile transport medium - send parental samples also (a total of 2 tubes needed on EACH parent; 3-4 mL of whole peripheral blood in Dark Green top Sodium Heparin tube AND 3-4 mL of whole peripheral blood in a Lavender top EDTA tube)

For Oncology Microarray SNP:   a total of 2 tubes needed; 3-4 mL of whole bone marrow or oncology blood in Dark Green top Sodium Heparin tube AND 3-4 mL of whole bone marrow or oncology blood in a Lavender top EDTA tube. The lab should be able to perform both Oncology FISH and Oncology Chromosome Analysis in addition to the Oncology Microarray SNP with the above sample requirements - so NO additional specimen is needed for those studies if the required 2 tubes are sent.

Collection personnel MUST initial specimen container to confirm sample identity. Label tubes with patient name and date of birth (DOB).


Pediatric Collection

Prenatal:  For twin pregnancies, label tubes with the mother's name and "TWIN A" on one fetal sample and "TWIN B" on the second fetal sample.

Performing Lab

Cytogenetics Laboratory 
Phone: (513) 636-4474
Fax: (513) 636-4414

Hours: Dayshift (Monday through Friday)

Remarks

Cincinnati Children's is an Illumina Certified Service Provider (CSPro).

Cincinnati Children’s Cytogenetics Laboratory is a CAP-accredited CLIA-certified clinical laboratory offering Microarray services to detect DNA copy number changes. Our knowledgeable and experienced team provides two service options for multiple sample types:

Tech Only with data generation or Full Service with data generation and comprehensive cytogenetic copy number data interpretation
Ordering

Synonyms

  • AMNIOTIC FLUID SNP MICROARRAY
  • PRENATAL MICROARRAY : SNP
  • SNP MICROARRAY
  • CHORIONIC VILLI (CVS) SNP MICROARRAY
  • CYTOGENETIC MICROARRAY
  • ONCOLOGY SNP MICROARRAY
  • 253 - MICROARRAY : SNP
  • Constitutional Microarray : SNP
  • MA SNP

Reflex Testing

If the MICROARRAY : SNP sample is for PRENATAL STUDIES (from amniotic fluid or chorionic villi), there will be an additional charge added for culture of the sample (CPT code 88240).

Methodology

Microarray analysis is performed using a SNP based microarray chip with over approximately 840,000 markers. This test is designed to identify chromosomal imbalances throughout the human genome including deletions, duplications, aneuploidy, and region of homozygosity. Our laboratory has established criteria for reporting abnormalities based on size, gene content, and clinical significance.

Reported

3 Weeks

Result Interpretation
Laboratory Personnel Use

CPT Codes

FOR Constitutional MA SNP:  81229
FOR Oncology MA SNP:  81277
PRENATAL SNP needing Tissue CULTURE:  add 88240 to Constitutional MA : SNP


Please call 1-866-450-4198 for pricing or with any billing questions.

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