Ordering Recommendations

May be helpful in evaluating for autoimmune liver disease. For a more comprehensive reflex panel, refer to Autoimmune Liver Disease Reflexive Panel (3002479).

Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.(Min: 0.25 mL)

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Unacceptable Conditions

Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Notes

In viral hepatitis the titers are generally less than 1:80 and are transient. The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.

If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply

Referral Lab

Laboratories.

Performed

Sun-Sat

Reported

1-5 days

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody

Reference Interval

Components
Reference Interval
F-Actin (Smooth Muscle) Ab, IgG by ELISA19 Units or less

Interpretive Data



F-Actin (Smooth Muscle) Antibody, IgGInterpretive Data
19 Units or lessNegative
20-30 UnitsWeak Positive - Suggest repeat testing in two or three weeks with a fresh specimen.
31 Units or greaterPositive - Suggestive of autoimmune hepatitis or chronic active hepatitis.

Synonyms

  • Actin Antibody Reflexive Panel
  • Anti-Smooth Muscle Antibody
  • ASMA Reflexive Panel
  • F-Actin Antibody Panel
  • SMA Reflexive Panel
  • Soft-SMA
  • F-Actin Antibody
  • Actin Antibody
  • SMA IgG Ab
  • SMA IgG
  • Smooth Muscle Antibodies
  • ASMA
  • SMA
  • 0051174

CPT Codes

86015; if reflexed, add 86256

LOINC

  • 44706-0

Interface Order Code (OBR)

SMAR

Interface Result Code (OBX)

ACTIN
Collecting

Ordering Recommendations

May be helpful in evaluating for autoimmune liver disease. For a more comprehensive reflex panel, refer to Autoimmune Liver Disease Reflexive Panel (3002479).

Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.(Min: 0.25 mL)

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Unacceptable Conditions

Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Notes

In viral hepatitis the titers are generally less than 1:80 and are transient. The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.

If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply

Referral Lab

Laboratories.
Resulting

Performed

Sun-Sat

Reported

1-5 days

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody

Reference Interval

Components
Reference Interval
F-Actin (Smooth Muscle) Ab, IgG by ELISA19 Units or less

Interpretive Data



F-Actin (Smooth Muscle) Antibody, IgGInterpretive Data
19 Units or lessNegative
20-30 UnitsWeak Positive - Suggest repeat testing in two or three weeks with a fresh specimen.
31 Units or greaterPositive - Suggestive of autoimmune hepatitis or chronic active hepatitis.

Additional Information

Synonyms

  • Actin Antibody Reflexive Panel
  • Anti-Smooth Muscle Antibody
  • ASMA Reflexive Panel
  • F-Actin Antibody Panel
  • SMA Reflexive Panel
  • Soft-SMA
  • F-Actin Antibody
  • Actin Antibody
  • SMA IgG Ab
  • SMA IgG
  • Smooth Muscle Antibodies
  • ASMA
  • SMA
  • 0051174
Coding

CPT Codes

86015; if reflexed, add 86256
Interface Mapping

LOINC

  • 44706-0

Interface Order Code (OBR)

SMAR

Interface Result Code (OBX)

ACTIN

ARUP Consult®

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