Detection of platelet-associated IgG and/or IgM may be used to separate thrombocytopenia of immune origin from nonimmune origin. Most patients with ITP have abnormally high levels of IgG associated with their platelets. Occasionally patients will have normal IgG levels but abnormally high levels of IgM. Dual staining and flow cytometric analysis ensures that only platelets are analyzed and relatively small volumes of blood are required. Reference: aruplab.com
Performed
Sunday - Saturday
Methodology
Flow Cytometry
Reported
3-4 days
Performing Lab
Send Outs
Referral Lab
ARUP Laboratories
Synonyms
7983
Platelet Associated Antibodies Direct IgG, IgM
Direct Platelet Antibody
Platelet Associated Immunoglobulins (IgG & IgM)
ARUP 0095614
Reference Interval
IgG: Negative
IgM: Negative
Interpretive Data
Negative (IgG & IgM): No excess antibodies were associated with the patient's platelets. An immune cause of thrombocytopenia is unlikely. Positive (IgG and/or IgM): An increase in platelet associated immunoglobulin is noted. An immune cause of thrombocytopenia should be considered. However, many conditions can result in an increase in platelet associated antibodies; for example, IgM rheumatoid factor antibodies. Strong Positive (IgG and/or IgM): A definite increase in platelet associated immunoglobulin is noted and an immune cause of thrombocytopenia should be considered. However, many conditions can result in an increase in platelet associated antibodies; for example, IgM rheumatoid factor antibodies
Detection of platelet-associated IgG and/or IgM may be used to separate thrombocytopenia of immune origin from nonimmune origin. Most patients with ITP have abnormally high levels of IgG associated with their platelets. Occasionally patients will have normal IgG levels but abnormally high levels of IgM. Dual staining and flow cytometric analysis ensures that only platelets are analyzed and relatively small volumes of blood are required. Reference: aruplab.com
Performed
Sunday - Saturday
Methodology
Flow Cytometry
Reported
3-4 days
Performing Lab
Send Outs
Referral Lab
ARUP Laboratories
Synonyms
7983
Platelet Associated Antibodies Direct IgG, IgM
Direct Platelet Antibody
Platelet Associated Immunoglobulins (IgG & IgM)
ARUP 0095614
Result Interpretation
Reference Interval
IgG: Negative
IgM: Negative
Interpretive Data
Negative (IgG & IgM): No excess antibodies were associated with the patient's platelets. An immune cause of thrombocytopenia is unlikely. Positive (IgG and/or IgM): An increase in platelet associated immunoglobulin is noted. An immune cause of thrombocytopenia should be considered. However, many conditions can result in an increase in platelet associated antibodies; for example, IgM rheumatoid factor antibodies. Strong Positive (IgG and/or IgM): A definite increase in platelet associated immunoglobulin is noted and an immune cause of thrombocytopenia should be considered. However, many conditions can result in an increase in platelet associated antibodies; for example, IgM rheumatoid factor antibodies
