Plasma not separated within 6 hours of collection.
Whole Blood frozen.
Specimen collected in heparin.
Specimen contains less than 1 mL of plasma.
Shared specimens that have been tested on the automation line in Chemistry or Hematology.
Collection Comments
Separate from cells within 24 hours of collection. Transfer 2mL plasma to an ARUP standard transport tube.
Storage/Transport Temperature
Refrigerated
Stability (from collection to initiation)
Room Temperature: Not Recommended
Refrigerated: 6 days
Frozen: 84 days
Special Handling
Spin within 6 hours; Refrigerate plasma
Ordering Recommendations
CMV infection remains a major cause of morbidity and mortality in both solid organ transplant patients and bone marrow transplant patients. The diagnostic challenge with CMV disease is to distinguish asymptomatic latent or low level persistent infectionfrom clinically significant disease. The use of plasma as a sample type may provide a better correlation with clinical disease than detection of CMV DNA from whole blood or leukocytes because it measures CMV DNA circulating in the blood stream which is adirect result of active viral replication rather than the latent intracellular CMV DNA. The Indiana University Health Molecular Pathology Laboratory has standardized to the International Standard with determining the conversion factor from copies/mL toIU/mL to be 1.41.
Performed
Monday - Saturday; Days
Methodology
RT-PCR
Reported
2-3 days
Performing Lab
Molecular
Synonyms
3112
CMVQN
Cytomegalovirus QN
Reference Interval
35-1.00 E7 copies/mL
Interpretive Data
Not Detected
Assay Limitation(s)
Negative test results do not preclude CMV infection or tissue-invasive CMV disease, and test results should therefore not be the sole basis for patient management decisions.
CPT Codes
87497
LOINC Codes
NAME
LOINC
Result
CMV DNA
30246-3
CMV PCR QN
72493-0
Log10 CMV PCR QN
72494-8
Test Code (Outreach Synonym)
3112
Catalog Code
1321302796
Collection
Collect
Blood, Lavender
Preferred Draw Volume
5 mL
Minimum Draw Volume
Whole Blood: 2 mL
Plasma: 1 mL
Other Acceptable Containers
Pearl
Unacceptable Conditions
Plasma not separated within 6 hours of collection.
Whole Blood frozen.
Specimen collected in heparin.
Specimen contains less than 1 mL of plasma.
Shared specimens that have been tested on the automation line in Chemistry or Hematology.
Collection Comments
Separate from cells within 24 hours of collection. Transfer 2mL plasma to an ARUP standard transport tube.
Storage/Transport Temperature
Refrigerated
Stability (from collection to initiation)
Room Temperature: Not Recommended
Refrigerated: 6 days
Frozen: 84 days
Special Handling
Spin within 6 hours; Refrigerate plasma
Ordering
Ordering Recommendations
CMV infection remains a major cause of morbidity and mortality in both solid organ transplant patients and bone marrow transplant patients. The diagnostic challenge with CMV disease is to distinguish asymptomatic latent or low level persistent infectionfrom clinically significant disease. The use of plasma as a sample type may provide a better correlation with clinical disease than detection of CMV DNA from whole blood or leukocytes because it measures CMV DNA circulating in the blood stream which is adirect result of active viral replication rather than the latent intracellular CMV DNA. The Indiana University Health Molecular Pathology Laboratory has standardized to the International Standard with determining the conversion factor from copies/mL toIU/mL to be 1.41.
Performed
Monday - Saturday; Days
Methodology
RT-PCR
Reported
2-3 days
Performing Lab
Molecular
Synonyms
3112
CMVQN
Cytomegalovirus QN
Result Interpretation
Reference Interval
35-1.00 E7 copies/mL
Interpretive Data
Not Detected
Assay Limitation(s)
Negative test results do not preclude CMV infection or tissue-invasive CMV disease, and test results should therefore not be the sole basis for patient management decisions.
