If you are an external healthcare provider with no access to Nationwide Children’s Epic system, submission of a completed Genetic Test Requisition Form is required. If you are an internal ordering provider with access to Nationwide Children’s Epic system, no requisition form is required; please place the lab order electronically in Epic.

Please specify which syndrome is suspected or which chromosome region/locus/probe should be tested by FISH analysis. If no specific syndrome or chromosome rearrangement is in question, then chromosomal microarray analysis should be ordered instead of FISH analysis (see test code: SNPMA). Call Cytogenetics Lab at (614) 722-5321 with questions or to perform testing on tissue types other than blood sample. If a structural chromosome rearrangement is in question, then high resolution chromosome analysis (test code: PBCS) may be recommended to be performed in conjunction with this FISH analysis.

Collect whole blood sample in sodium heparin tube (dark green-top tube without gel separator). Do NOT use lithium heparin or other types of heparin tubes; check tube for proper heparin type. FISH analysis will be performed on metaphase cells from cultured blood lymphocytes and specific FISH probe required for the study may need to be ordered from an external vendor; therefore, FISH result from this testing typically takes 3 weeks.

This test uses fluorescence in situ hybridization (FISH) probe specific for a chromosome region in question to assess the presence/absence and copy number of the chromosome region in the patient. This FISH analysis is used to test for:

• Common chromosome microdeletion or microduplication syndromes such as DiGeorge (22q11.2 deletion) syndrome.
• Presence or absence of the SRY gene (male sex determining gene) in patients with ambiguous genitalia who had an apparently normal karyotype.
• Custom FISH analysis is available to evaluate for presence of mosaicism, to further characterize a marker chromosome, to confirm chromosome rearrangements identified on chromosome analysis or microarray analysis (e.g. translocations, inversions, and insertions), and to evaluate for known familial chromosome rearrangements. For familial study, a sample from the family member who carries the cytogenetic abnormality may be required to use as a positive control.

If you are an external healthcare provider with no access to Nationwide Children’s Epic system, submission of a completed Genetic Test Requisition Form is required. If you are an internal ordering provider with access to Nationwide Children’s Epic system, no requisition form is required; please place the lab order electronically in Epic.

Please specify which syndrome is suspected or which chromosome region/locus/probe should be tested by FISH analysis. If no specific syndrome or chromosome rearrangement is in question, then chromosomal microarray analysis should be ordered instead of FISH analysis (see test code: SNPMA). Call Cytogenetics Lab at (614) 722-5321 with questions or to perform testing on tissue types other than blood sample. If a structural chromosome rearrangement is in question, then high resolution chromosome analysis (test code: PBCS) may be recommended to be performed in conjunction with this FISH analysis.

Collect whole blood sample in sodium heparin tube (dark green-top tube without gel separator). Do NOT use lithium heparin or other types of heparin tubes; check tube for proper heparin type. FISH analysis will be performed on metaphase cells from cultured blood lymphocytes and specific FISH probe required for the study may need to be ordered from an external vendor; therefore, FISH result from this testing typically takes 3 weeks.

This test uses fluorescence in situ hybridization (FISH) probe specific for a chromosome region in question to assess the presence/absence and copy number of the chromosome region in the patient. This FISH analysis is used to test for:

• Common chromosome microdeletion or microduplication syndromes such as DiGeorge (22q11.2 deletion) syndrome.
• Presence or absence of the SRY gene (male sex determining gene) in patients with ambiguous genitalia who had an apparently normal karyotype.
• Custom FISH analysis is available to evaluate for presence of mosaicism, to further characterize a marker chromosome, to confirm chromosome rearrangements identified on chromosome analysis or microarray analysis (e.g. translocations, inversions, and insertions), and to evaluate for known familial chromosome rearrangements. For familial study, a sample from the family member who carries the cytogenetic abnormality may be required to use as a positive control.

This test uses fluorescence in situ hybridization (FISH) probe specific for a chromosome region in question to assess the presence/absence and copy number of the chromosome region in the patient. This FISH analysis is used to test for:

• Common chromosome microdeletion or microduplication syndromes such as DiGeorge (22q11.2 deletion) syndrome.
• Presence or absence of the SRY gene (male sex determining gene) in patients with ambiguous genitalia who had an apparently normal karyotype.
• Custom FISH analysis is available to evaluate for presence of mosaicism, to further characterize a marker chromosome, to confirm chromosome rearrangements identified on chromosome analysis or microarray analysis (e.g. translocations, inversions, and insertions), and to evaluate for known familial chromosome rearrangements. For familial study, a sample from the family member who carries the cytogenetic abnormality may be required to use as a positive control.

If you are an external healthcare provider with no access to Nationwide Children’s Epic system, submission of a completed Genetic Test Requisition Form is required. If you are an internal ordering provider with access to Nationwide Children’s Epic system, no requisition form is required; please place the lab order electronically in Epic.

Please specify which syndrome is suspected or which chromosome region/locus/probe should be tested by FISH analysis. If no specific syndrome or chromosome rearrangement is in question, then chromosomal microarray analysis should be ordered instead of FISH analysis (see test code: SNPMA). Call Cytogenetics Lab at (614) 722-5321 with questions or to perform testing on tissue types other than blood sample. If a structural chromosome rearrangement is in question, then high resolution chromosome analysis (test code: PBCS) may be recommended to be performed in conjunction with this FISH analysis.

Collect whole blood sample in sodium heparin tube (dark green-top tube without gel separator). Do NOT use lithium heparin or other types of heparin tubes; check tube for proper heparin type. FISH analysis will be performed on metaphase cells from cultured blood lymphocytes and specific FISH probe required for the study may need to be ordered from an external vendor; therefore, FISH result from this testing typically takes 3 weeks.

This test uses fluorescence in situ hybridization (FISH) probe specific for a chromosome region in question to assess the presence/absence and copy number of the chromosome region in the patient. This FISH analysis is used to test for:

• Common chromosome microdeletion or microduplication syndromes such as DiGeorge (22q11.2 deletion) syndrome.
• Presence or absence of the SRY gene (male sex determining gene) in patients with ambiguous genitalia who had an apparently normal karyotype.
• Custom FISH analysis is available to evaluate for presence of mosaicism, to further characterize a marker chromosome, to confirm chromosome rearrangements identified on chromosome analysis or microarray analysis (e.g. translocations, inversions, and insertions), and to evaluate for known familial chromosome rearrangements. For familial study, a sample from the family member who carries the cytogenetic abnormality may be required to use as a positive control.