Refer to Specimen stability criteria as shown below
Ambient
72 hours
Refrigerated
7 days
Frozen
14 days
Unacceptable Conditions
Specimens that exceed stated stability, unlabeled/mislabeled/mismatched specimens, specimens submitted in leaking containers
Special Instructions
This test requires its own lavender top. Collecting sample just before the next dose will be adequate for monitoring purposes. Optimal response to Tacrolimus is usually associated with the trough blood concentration (i.e., the minimum concentration experienced just before the next dose).
CPT Codes
80197
Synonyms
FK506
Prograf
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS)
Performing Location
Chemistry (Toxicology)
Reported STAT
Not available
Reported Routine
4 - 6 hours
Additional Information
Test developed and performance characteristics determined by University of California Irvine Medical Center, Department of Pathology and Laboratory Medicine. It has not been cleared or approved by the FDA, however, FDA approval is not required for clinical use.
Test set up frequency
Daily (Cut-off time 12:00 Noon)
Reference Interval
Therapeutic ranges must be established by physician.
For solid organ transplants:
Adults: 8 - 15 ng/mL
Pediatric: 2 - 5 ng/mL
Critical value (automatic call-back):
Adults: >20 ng/mL
Pediatric: >7.5 ng/mL
Additional Information
Test developed and performance characteristics determined by University of California Irvine Medical Center, Department of Pathology and Laboratory Medicine. It has not been cleared or approved by the FDA, however, FDA approval is not required for clinical use.
Collection
Collect
3.0 mL whole blood in lavender-top (EDTA) tube(s)
Specimen Required
1.0 mL whole blood
Specimen Min Vol
0.5 mL whole blood
Specimen Preparation
None
Storage/Transport Temperature
Refer to Specimen stability criteria as shown below
Ambient
72 hours
Refrigerated
7 days
Frozen
14 days
Unacceptable Conditions
Specimens that exceed stated stability, unlabeled/mislabeled/mismatched specimens, specimens submitted in leaking containers
Special Instructions
This test requires its own lavender top. Collecting sample just before the next dose will be adequate for monitoring purposes. Optimal response to Tacrolimus is usually associated with the trough blood concentration (i.e., the minimum concentration experienced just before the next dose).
Test Info
CPT Codes
80197
Synonyms
FK506
Prograf
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS)
Performing Location
Chemistry (Toxicology)
Reported STAT
Not available
Reported Routine
4 - 6 hours
Additional Information
Test developed and performance characteristics determined by University of California Irvine Medical Center, Department of Pathology and Laboratory Medicine. It has not been cleared or approved by the FDA, however, FDA approval is not required for clinical use.
Test set up frequency
Daily (Cut-off time 12:00 Noon)
Result Interpretation
Reference Interval
Therapeutic ranges must be established by physician.
For solid organ transplants:
Adults: 8 - 15 ng/mL
Pediatric: 2 - 5 ng/mL
Critical value (automatic call-back):
Adults: >20 ng/mL
Pediatric: >7.5 ng/mL
Additional Information
Test developed and performance characteristics determined by University of California Irvine Medical Center, Department of Pathology and Laboratory Medicine. It has not been cleared or approved by the FDA, however, FDA approval is not required for clinical use.
