EPIC Code

LAB380

Performing Lab

ARUP Laboratories

Collect

24 hour urine. Refrigerate during collection. Specimen must be collected in a plastic container. Also acceptable: Random urine.

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and nonessential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours postexposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days postcontrast media exposure.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787. (Min: 1 mL)

Unacceptable Conditions

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media.. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Performed

Sun-Sat

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year

Remarks

Record total volume and collection time interval on transport tube and on test request form.

Notes

High concentrations of iodine or gadolinium may interfere with elemental testing.

Referral Lab

Laboratories.

Performed

Sun-Sat

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reported

1-5 days

Synonyms

  • Cu, Urine
  • LAB380
  • CU-URINE
  • 24-hour urine copper
  • Copper/Creatinine Ratio, Urine
  • Cu
  • CUU
  • Normalized Urine Copper
  • Normalized Urine Cu

Additional Technical Information

Ordering Recommendations

Useful in the assessment of overload.

EPIC Code

LAB380

Reference Interval

Components
Reference Interval
Copper, Urine - per volumeLess than or equal to 3.2 µg/dL
Copper, Urine - per 24h3.0-45.0 µg/d
Creatinine, Urine - per 24h
Age
Male (mg/d)
Female (mg/d)
3-8 years140-700140-700
9-12 years300-1300300-1300
13-17 years500-2300400-1600
18-50 years1000-2500700-1600
51-80 years800-2100500-1400
81 years and older600-2000400-1300

Copper, Urine - ratio to CRT10.0-45.0 µg/g CRT

Interpretive Data

Individuals with symptomatic Wilson disease usually excrete more than 100 µg copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, a 24-hour collection is a more consistent indicator of copper urine.

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

CPT Codes

82525
Collection

EPIC Code

LAB380

Performing Lab

ARUP Laboratories

Collect

24 hour urine. Refrigerate during collection. Specimen must be collected in a plastic container. Also acceptable: Random urine.

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and nonessential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours postexposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days postcontrast media exposure.

Specimen Preparation

Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787. (Min: 1 mL)

Unacceptable Conditions

Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media.. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Performed

Sun-Sat

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year

Remarks

Record total volume and collection time interval on transport tube and on test request form.

Notes

High concentrations of iodine or gadolinium may interfere with elemental testing.

Referral Lab

Laboratories.
Ordering

Performed

Sun-Sat

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reported

1-5 days

Synonyms

  • Cu, Urine
  • LAB380
  • CU-URINE
  • 24-hour urine copper
  • Copper/Creatinine Ratio, Urine
  • Cu
  • CUU
  • Normalized Urine Copper
  • Normalized Urine Cu

Additional Technical Information

Ordering Recommendations

Useful in the assessment of overload.

EPIC Code

LAB380

Result Interpretation

Reference Interval

Components
Reference Interval
Copper, Urine - per volumeLess than or equal to 3.2 µg/dL
Copper, Urine - per 24h3.0-45.0 µg/d
Creatinine, Urine - per 24h
Age
Male (mg/d)
Female (mg/d)
3-8 years140-700140-700
9-12 years300-1300300-1300
13-17 years500-2300400-1600
18-50 years1000-2500700-1600
51-80 years800-2100500-1400
81 years and older600-2000400-1300

Copper, Urine - ratio to CRT10.0-45.0 µg/g CRT

Interpretive Data

Individuals with symptomatic Wilson disease usually excrete more than 100 µg copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, a 24-hour collection is a more consistent indicator of copper urine.

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

Administrative

CPT Codes

82525

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