Optimize drug therapy and monitor patient adherence.
Patient Preparation
Timing of specimen collection: Predose (trough) draw at steady state concentration.
Collect
Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.3 mL)
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
After separation from cells: Ambient: 7 days; Refrigerated: 1 week; Frozen: 1 month
Unacceptable Conditions
Serum or plasma separator tubes. Grossly hemolyzed specimens.
Therapeutic range: : 10-40 µg/mL Toxic: Not well established
Interpretive Data
Pharmacokinetics of levetiracetam are affected by renal function. Adverse effects may include somnolence, weakness, headache and vomiting.
This levetiracetam (Keppra) immunoassay uses the ARK Diagnostics reagents, which has known cross-reactivity with the drug brivaracetam (Briviact) and may report inaccurate results. Patients transitioning from levetiracetam to brivaracetam or those who are using both medications should not monitor drug concentrations with the ARK Diagnostics assay. These patients should be monitored using a validated chromatographic methodology that distinguishes between drugs to determine drug concentrations.
Synonyms
keppra blood concentration
Keppra concentration
Levetiracetam
Keppra
Keppra level, Keppra blood level
anti-epileptic
0098627
CPT Codes
80177
LOINC
30471-7
Interface Order Code (OBR)
KEPPRA
Interface Result Code (OBX)
KEPPR1
Collecting
Ordering Recommendations
Optimize drug therapy and monitor patient adherence.
Patient Preparation
Timing of specimen collection: Predose (trough) draw at steady state concentration.
Collect
Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.3 mL)
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
After separation from cells: Ambient: 7 days; Refrigerated: 1 week; Frozen: 1 month
Unacceptable Conditions
Serum or plasma separator tubes. Grossly hemolyzed specimens.
Therapeutic range: : 10-40 µg/mL Toxic: Not well established
Interpretive Data
Pharmacokinetics of levetiracetam are affected by renal function. Adverse effects may include somnolence, weakness, headache and vomiting.
This levetiracetam (Keppra) immunoassay uses the ARK Diagnostics reagents, which has known cross-reactivity with the drug brivaracetam (Briviact) and may report inaccurate results. Patients transitioning from levetiracetam to brivaracetam or those who are using both medications should not monitor drug concentrations with the ARK Diagnostics assay. These patients should be monitored using a validated chromatographic methodology that distinguishes between drugs to determine drug concentrations.
Laboratories.