Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL to an ARUP standard transport tube. (Min: 0.3 mL)

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.

Performed

Sun-Sat

Referral Lab

Laboratories.

Ordering Recommendations

May be useful in confirming a diagnosis of primary biliary cholangitis.

Performing Lab

ARUP Laboratories

Reported

1-2 days

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Synonyms

  • AMA
  • Anti-Mitochondrial Antibody
  • Antibodies to Microtubule Associated Protein 2
  • Antimitochondrial Antibodies
  • Immunology Profile (AMA)
  • Mitochondrial Antibodies, Serum

Reference Interval

Components
Reference Interval
Mitochondrial (M2) Antibody, IgG24.9 Units or less

Interpretive Data

Antimitochondrial antibodies (AMA) are thought to be present in 90-95% of patients with primary biliary cholangitis (PBC). However, the frequency of detected antibodies may be cohort or assay dependent, as lower sensitivities have been reported. Not all PBC patients are positive for AMA; some patients may be positive for SP100 and/or GP210 antibodies. A negative result does not rule out PBC.

Component
Interpretation
Mitochondrial M2 Antibody, IgG (ELISA)20.0 Units or less              Negative
20.1-24.9                          Equivocal
25.0 Units or greater         Positive

CPT Codes

86381

LOINC

  • 14251-3
Collection

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL to an ARUP standard transport tube. (Min: 0.3 mL)

Stability (from collection to initiation)

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.

Performed

Sun-Sat

Referral Lab

Laboratories.
Ordering

Ordering Recommendations

May be useful in confirming a diagnosis of primary biliary cholangitis.

Performing Lab

ARUP Laboratories

Reported

1-2 days

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Synonyms

  • AMA
  • Anti-Mitochondrial Antibody
  • Antibodies to Microtubule Associated Protein 2
  • Antimitochondrial Antibodies
  • Immunology Profile (AMA)
  • Mitochondrial Antibodies, Serum
Result Interpretation

Reference Interval

Components
Reference Interval
Mitochondrial (M2) Antibody, IgG24.9 Units or less

Interpretive Data

Antimitochondrial antibodies (AMA) are thought to be present in 90-95% of patients with primary biliary cholangitis (PBC). However, the frequency of detected antibodies may be cohort or assay dependent, as lower sensitivities have been reported. Not all PBC patients are positive for AMA; some patients may be positive for SP100 and/or GP210 antibodies. A negative result does not rule out PBC.

Component
Interpretation
Mitochondrial M2 Antibody, IgG (ELISA)20.0 Units or less              Negative
20.1-24.9                          Equivocal
25.0 Units or greater         Positive

Administrative

CPT Codes

86381

LOINC

  • 14251-3

ARUP Consult®

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