Useful as a component of the diagnosis of Celiac disease and for monitoring patient compliance with a gluten free diet. This test is intended as an aid in the diagnosis and monitoring of Celiac disease and is not definitive in isolation.
Collection Container
Collect
2 mL Serum, Gold (SST) top tube
Pediatric Collection
This assay has not been validated for pediatric population.
Storage/Transport Temperature
Ambient or refrigerated
Stability (from collection to initiation)
Refrigerated 48 hours;Otherwise aliquot and freeze at -20C.
Unacceptable Conditions
Grossly hemolyzed, icteric or lipemic samples as well as samples containing particulate matter or exhibiting obvious microbial contamination.
Processing - HUP
Spin specimen 7-10 minutes. Hold for Immunology.
Processing - PAH
Spin 7-10 minutes. Prepare specimen for courier pickup
Processing - Presbyterian
Spin 7-10 minutes. Prepare specimen for courier pickup.
Processing - HUP Cedar
Spin 7-10 minutes. Prepare specimen for courier pickup.
Reference Interval
0-19 units
Interpretive Data and Information
Negative: 0-19 units
Weak positive: 20-30 units
Moderate to Strong positive: >30 units
Testing Limitations
False positive results can occur in other gastrointestinal disorders, e.g., milk protein intolerance and post infection malabsorption.
Clinical Significance
A negative Gliadin IgA result in an untreated patient does not rule out gluten-sensitive enteropathy, particularly when associated with high levels of gliadin IgG antibodies. The finding often results from selective IgA deficiency, a relatively frequent finding in Celiac disease. In treated patients known to express IgA antibodies, Gliadin IgA antibody levels represent a better indicator of dietary compliance than Gliadin IgG antibody levels.
CPT Codes
83516
LOINC
63453-5
63459-2
Collection & Processing
Ordering Recommendations
Useful as a component of the diagnosis of Celiac disease and for monitoring patient compliance with a gluten free diet. This test is intended as an aid in the diagnosis and monitoring of Celiac disease and is not definitive in isolation.
Collection Container
Collect
2 mL Serum, Gold (SST) top tube
Pediatric Collection
This assay has not been validated for pediatric population.
Storage/Transport Temperature
Ambient or refrigerated
Stability (from collection to initiation)
Refrigerated 48 hours;Otherwise aliquot and freeze at -20C.
Unacceptable Conditions
Grossly hemolyzed, icteric or lipemic samples as well as samples containing particulate matter or exhibiting obvious microbial contamination.
CR&P Information
Processing - HUP
Spin specimen 7-10 minutes. Hold for Immunology.
Processing - PAH
Spin 7-10 minutes. Prepare specimen for courier pickup
Processing - Presbyterian
Spin 7-10 minutes. Prepare specimen for courier pickup.
Processing - HUP Cedar
Spin 7-10 minutes. Prepare specimen for courier pickup.
Result Interpretation
Reference Interval
0-19 units
Interpretive Data and Information
Negative: 0-19 units
Weak positive: 20-30 units
Moderate to Strong positive: >30 units
Testing Limitations
False positive results can occur in other gastrointestinal disorders, e.g., milk protein intolerance and post infection malabsorption.
Clinical Significance
A negative Gliadin IgA result in an untreated patient does not rule out gluten-sensitive enteropathy, particularly when associated with high levels of gliadin IgG antibodies. The finding often results from selective IgA deficiency, a relatively frequent finding in Celiac disease. In treated patients known to express IgA antibodies, Gliadin IgA antibody levels represent a better indicator of dietary compliance than Gliadin IgG antibody levels.
