Chromosome analysis is performed on cells following exposure to mutagens (diepoxybutane and mitomycin C) to determine mutagen sensitivity. This test is useful for differential diagnoses of idiopathic aplastic anemia and Fanconi anemia.
Common reasons for this test include:
Limitations:
A minimum of 4 million cells is required to ensure sufficient capacity for testing. Specimens containing fewer than 4 million cells may be insufficient for testing. Cell culture and chromosome analysis success cannot be guaranteed. Various factors may influence the success of culture growth and chromosome analysis. Cell cultures are discarded after all cytogenetic testing is completed and reported.
For questions about this test, please contact the Cytogenetics Laboratory at 612-273-3171.
Test request form requires:
A signed informed consent in the patient's medical record is required. The consent should not be sent to the laboratory. A link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors. See Associated Links.
Results are reported within 7-14 days.
Whole blood.
5 mL
3 mL
1-3 mL will be accepted for patients with blood draw limitations. No heel sticks or finger sticks accepted.
Store at room temperature. Do NOT refrigerate or freeze. Do not process.
Clotted or frozen specimen. Incorrect specimen collection tube (anticoagulant).
Ship at room temperature.
For optimal testing results the specimen must arrive within 24 hours.
Green (Sodium Heparin, No Gel)
| Requester | Contact Information |
| Patient and UMP/FV Care Team | Fairview Consumer Line at 612-672-1048 |
| MRL Outreach Client | dept-mrl-business-assessment@fairview.org |
| Research | research@fairview.org |
| CPT | Qty | HC Hospital | PR Clinic | Note |
| 88230 | 1 | 3108823005 | 8823005 | CHROM CULT FAN ANEMIA |
| 88249 | 1 | 3108824901 | 8824901 | CHROM ANALYSIS FAN ANEMIA |
| 88291 | 1 | 9718829101 | HC CYTOGENETICS INTERP PF | |
| 88291 | 1 | 8829101 | PR CYTOGENETICS&MOLEC CYTOGENETICS INTERP&REP |
Additional CPT codes may be charged if additional work is needed to interpret patient results. The culture fee (88230) may still apply if a specimen does not yield sufficient growth for complete analysis.
Chromosome breakage analysis.
| Test Name | Component | Required | Description | Type | LOINC |
| LAB4755 | Chromosome Fanconi Mutagen Sensitivity | Orderable | |||
| 127025 | Y | Clinical indications for testing: | Prompt | ||
| 158442 | Y | Interpretation request: | Prompt | ||
| 158445 | Y | Family history: | Prompt | ||
| 158446 | Y | Previous cytogenetic studies: | Prompt | ||
| 158924 | Previous history: | Prompt | |||
| QUE_NRBC | Nucleated RBC count (if patient <1w old) | Prompt | |||
| SRC_1001 | Y | Blood specimen source: | Prompt | ||
| 1230000027 | Methods Cytogenetics | Result | |||
| 1230000029 | Results Cytogenetics | Result | |||
| 1230000030 | Interpretation Cytogenetics | Result | |||
| 1230000031 | Additional Comments | Result | |||
| 1230005210 | Signout Location if Remote | Result | 90119-9 |
| Ordering |
Chromosome analysis is performed on cells following exposure to mutagens (diepoxybutane and mitomycin C) to determine mutagen sensitivity. This test is useful for differential diagnoses of idiopathic aplastic anemia and Fanconi anemia.
Common reasons for this test include:
Limitations:
A minimum of 4 million cells is required to ensure sufficient capacity for testing. Specimens containing fewer than 4 million cells may be insufficient for testing. Cell culture and chromosome analysis success cannot be guaranteed. Various factors may influence the success of culture growth and chromosome analysis. Cell cultures are discarded after all cytogenetic testing is completed and reported.
For questions about this test, please contact the Cytogenetics Laboratory at 612-273-3171.
Test request form requires:
A signed informed consent in the patient's medical record is required. The consent should not be sent to the laboratory. A link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors. See Associated Links.
Results are reported within 7-14 days.
| Collection & Processing |
Whole blood.
5 mL
3 mL
1-3 mL will be accepted for patients with blood draw limitations. No heel sticks or finger sticks accepted.
Store at room temperature. Do NOT refrigerate or freeze. Do not process.
Clotted or frozen specimen. Incorrect specimen collection tube (anticoagulant).
Ship at room temperature.
For optimal testing results the specimen must arrive within 24 hours.
| Containers |
Green (Sodium Heparin, No Gel)
| Result Interpretation |
| Administrative |
| Requester | Contact Information |
| Patient and UMP/FV Care Team | Fairview Consumer Line at 612-672-1048 |
| MRL Outreach Client | dept-mrl-business-assessment@fairview.org |
| Research | research@fairview.org |
| CPT | Qty | HC Hospital | PR Clinic | Note |
| 88230 | 1 | 3108823005 | 8823005 | CHROM CULT FAN ANEMIA |
| 88249 | 1 | 3108824901 | 8824901 | CHROM ANALYSIS FAN ANEMIA |
| 88291 | 1 | 9718829101 | HC CYTOGENETICS INTERP PF | |
| 88291 | 1 | 8829101 | PR CYTOGENETICS&MOLEC CYTOGENETICS INTERP&REP |
Additional CPT codes may be charged if additional work is needed to interpret patient results. The culture fee (88230) may still apply if a specimen does not yield sufficient growth for complete analysis.
Chromosome breakage analysis.
| Interface Mapping |
| Test Name | Component | Required | Description | Type | LOINC |
| LAB4755 | Chromosome Fanconi Mutagen Sensitivity | Orderable | |||
| 127025 | Y | Clinical indications for testing: | Prompt | ||
| 158442 | Y | Interpretation request: | Prompt | ||
| 158445 | Y | Family history: | Prompt | ||
| 158446 | Y | Previous cytogenetic studies: | Prompt | ||
| 158924 | Previous history: | Prompt | |||
| QUE_NRBC | Nucleated RBC count (if patient <1w old) | Prompt | |||
| SRC_1001 | Y | Blood specimen source: | Prompt | ||
| 1230000027 | Methods Cytogenetics | Result | |||
| 1230000029 | Results Cytogenetics | Result | |||
| 1230000030 | Interpretation Cytogenetics | Result | |||
| 1230000031 | Additional Comments | Result | |||
| 1230005210 | Signout Location if Remote | Result | 90119-9 |
| Private Details |
