Special Instructions

For blood (including serum or plasma), use HSV12B

Use HSV12S for:
     - bronchoalveolar lavage (BAL),
     - amniotic fluid,
     - ocular fluid,
     - tissue or
     - endocervical specimen in ThinPrep Pap Test media

Ordering Recommendations

Order when any of the following are present and/or suspected:
  • Orolabial infection
  • Urogenital infection
  • Meningoencephalitis
  • Neonatal disease acquired by exposure to infected secretions during birth
  • Infection from herpes simplex virus is suspected
  • Viral encephalitis
  • Malaise, fever, headache and nausea with acute encephalopathy symptoms including lethargy, confusion and delirium

Collect

1-3 mL CSF (cerebral spinal fluid)
or
Cutaneous or mucocutaneous lesion swab in UTM, UVT/VTM, or M4

Collect, Minimum Volume

0.5 mL CSF 

Pediatric Collection

0.2 mL CSF

Specimen Preparation, Minimum Volume

CSF: 0.5 mL for adults, or 0.2 mL for pediatric patients

Storage/Transport Temperature

Refrigerated

Stability (from collection to initiation)

Ambient: Unacceptable
Refrigerated: 7 days
Frozen: >7 days at -70 C 

Unacceptable Conditions

Charcoal swabs
Gel swabs

Performed

Sunday-Saturday

Reported

Next day

Methodology

Real time PCR

Reference Interval

HSV-1: Not Detected
HSV-2: Not Detected

Lab Department

Molecular Pathology

Testing Location

Central Laboratory

Includes

HSV-1
HSV-2

Synonyms

  • Herpes Simplex Virus subtype 1 and 2
  • HSV
  • HSV1&2
  • HSV 1 and 2
  • HSV Type 1 and 2
  • HSVPCR

CPT Codes

87529 x2

Updated

6/26/2025
Collecting

Special Instructions

For blood (including serum or plasma), use HSV12B

Use HSV12S for:
     - bronchoalveolar lavage (BAL),
     - amniotic fluid,
     - ocular fluid,
     - tissue or
     - endocervical specimen in ThinPrep Pap Test media

Ordering Recommendations

Order when any of the following are present and/or suspected:
  • Orolabial infection
  • Urogenital infection
  • Meningoencephalitis
  • Neonatal disease acquired by exposure to infected secretions during birth
  • Infection from herpes simplex virus is suspected
  • Viral encephalitis
  • Malaise, fever, headache and nausea with acute encephalopathy symptoms including lethargy, confusion and delirium

Collect

1-3 mL CSF (cerebral spinal fluid)
or
Cutaneous or mucocutaneous lesion swab in UTM, UVT/VTM, or M4

Collect, Minimum Volume

0.5 mL CSF 

Pediatric Collection

0.2 mL CSF

Specimen Preparation, Minimum Volume

CSF: 0.5 mL for adults, or 0.2 mL for pediatric patients

Storage/Transport Temperature

Refrigerated

Stability (from collection to initiation)

Ambient: Unacceptable
Refrigerated: 7 days
Frozen: >7 days at -70 C 

Unacceptable Conditions

Charcoal swabs
Gel swabs
Resulting

Performed

Sunday-Saturday

Reported

Next day

Methodology

Real time PCR

Reference Interval

HSV-1: Not Detected
HSV-2: Not Detected
Additional Information

Lab Department

Molecular Pathology

Testing Location

Central Laboratory

Includes

HSV-1
HSV-2

Synonyms

  • Herpes Simplex Virus subtype 1 and 2
  • HSV
  • HSV1&2
  • HSV 1 and 2
  • HSV Type 1 and 2
  • HSVPCR
Coding

CPT Codes

87529 x2

Updated

6/26/2025
Interface Mapping

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