Timing of specimen collection: Predose (trough) draw at steady state concentration.
Collect
Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Additional Requirements
Collect: RED TOP TUBE (SERUM) / CAN NOT ADD TEST
Auto Lab Accepts:
Unacceptable Conditions
Serum or plasma separator tubes. Grossly hemolyzed specimens.
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.3 mL)
Ordering Recommendations
Optimize drug therapy and monitor patient adherence.
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
After separation from cells: Ambient: 7 days; Refrigerated: 1 week; Frozen: 1 month
Performed
Sun-Sat
Reported
Within 24 hours
Lab info
Specimens are sent by the Core Laboratory to ARUP Laboratory.
Section
Reference Laboratory-ARUP Laboratories
Reference Laboratory Test Code
0098627
Methodology
Quantitative Enzyme Immunoassay (EIA)
Synonyms
Keppra concentration
Keppra level, Keppra blood level
Levetiracetam
anti-epileptic
Keppra
keppra blood concentration
Reference Interval
Effective February 22, 2022
Therapeutic range: : 10-40 µg/mL Toxic: Not well established
Interpretive Data
Pharmacokinetics of levetiracetam are affected by renal function. Adverse effects may include somnolence, weakness, headache and vomiting.
This levetiracetam (Keppra) immunoassay uses the ARK Diagnostics reagents, which has known cross-reactivity with the drug brivaracetam (Briviact) and may report inaccurate results. Patients transitioning from levetiracetam to brivaracetam or those who are using both medications should not monitor drug concentrations with the ARK Diagnostics assay. These patients should be monitored using a validated chromatographic methodology that distinguishes between drugs to determine drug concentrations.
ARUP Test Code
0098627
LOINC
30471-7
CPT Codes
80177
Test Information
EPIC Lab Number
LAB4496
Patient Preparation
Timing of specimen collection: Predose (trough) draw at steady state concentration.
Collect
Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Additional Requirements
Collect: RED TOP TUBE (SERUM) / CAN NOT ADD TEST
Auto Lab Accepts:
Unacceptable Conditions
Serum or plasma separator tubes. Grossly hemolyzed specimens.
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.3 mL)
Ordering Recommendations
Optimize drug therapy and monitor patient adherence.
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
After separation from cells: Ambient: 7 days; Refrigerated: 1 week; Frozen: 1 month
Performed
Sun-Sat
Reported
Within 24 hours
Lab info
Specimens are sent by the Core Laboratory to ARUP Laboratory.
Section
Reference Laboratory-ARUP Laboratories
Reference Laboratory Test Code
0098627
Methodology
Quantitative Enzyme Immunoassay (EIA)
Synonyms
Keppra concentration
Keppra level, Keppra blood level
Levetiracetam
anti-epileptic
Keppra
keppra blood concentration
Reference Interval
Effective February 22, 2022
Therapeutic range: : 10-40 µg/mL Toxic: Not well established
Interpretive Data
Pharmacokinetics of levetiracetam are affected by renal function. Adverse effects may include somnolence, weakness, headache and vomiting.
This levetiracetam (Keppra) immunoassay uses the ARK Diagnostics reagents, which has known cross-reactivity with the drug brivaracetam (Briviact) and may report inaccurate results. Patients transitioning from levetiracetam to brivaracetam or those who are using both medications should not monitor drug concentrations with the ARK Diagnostics assay. These patients should be monitored using a validated chromatographic methodology that distinguishes between drugs to determine drug concentrations.
