Coagulation

Chemistry, Central Lab Sorrento Mesa                                                       Updated:  04/19/2023
 

Collect

SST (Min Vol 1 mL)

**NOT for maternal serum or amniotic fluid**
 

Storage/Transport Temperature

Transport refrigerated (2-8°C)
 

Stability (from collection to initiation)

Room temperature:  3 days
Refrigerated:  7 days
Frozen  -20°C or colder Aliquot:  for longer storage

Avoid more than 5 freeze/thaw cycle
 

Performed

Daily

Ordering Recommendations

The Alinity i AFP assay is a chemiluminescent microparticle immunoassay (CMIA) used for the quantitative determination of alpha-fetoprotein (AFP) on the Alinity i analyzer in human serum to aid in monitoring disease progression during the course of disease and treatment of patients with nonseminomatous testicular cancer.

Methodology

Abbott – Alinity
Methodology: Chemiluminescent microparticle immunoassay (CMIA)

Synonyms

  • Alpha-Fetoprotein
  • LAB559
  • AFP

Notes

Limitations of the procedure:

• If the AFP results are inconsistent with clinical evidence, additional testing is suggested to confirm the result.
• For diagnostic purposes, results should be used in conjunction with other data; e.g., symptoms, results of other tests, clinical impressions, etc.
• Specimens from patients who have received preparations of mouse monoclonal antibodies for diagnosis or therapy may contain human anti-mouse antibodies (HAMA). Specimens
containing HAMA may produce anomalous values when tested with assay kits such as Alinity i AFP that employ mouse monoclonal antibodies.
• Heterophilic antibodies in human serum can react with reagent immunoglobulins, interfering with in vitro immunoassays. Patients routinely exposed to animals or to animal serum products can be prone to this interference and anomalous results may be observed. Additional information may be required for diagnosis.
• Although the Alinity i AFP assay is specifically designed to minimize the effects of HAMA and heterophilic antibodies, assay results that are not consistent with other clinical observations may require additional information for diagnosis.
• The Alinity i AFP assay is a valuable aid in the management of nonseminomatous testicular cancer patients when used in conjunction with information available from the clinical evaluation and other diagnostic procedures. Increased serum AFP concentrations have also been observed in ataxia telangiectasia, hereditary tyrosinemia, primary hepatocellular carcinoma, teratocarcinoma, gastrointestinal tract cancers with and without liver metastases and in benign hepatic conditions such as acute viral hepatitis, chronic active hepatitis and cirrhosis.
• The Alinity i AFP assay should not be used as a cancer screening test.

Specimens get discarded after 7 days

 

Reference Interval

0 up to 1 Months: >2,000.00 ng/mL

1 Months up to 6 Months: 10.00-1,359.00 ng/mL

6 Months up to 1 Years: 0.00-103.00 ng/mL

1 Years up to 19 Years: 2.00-35.00 ng/mL

19 Years up to Unspecified: 2.00-8.78 ng/mL

CPT Codes

82105
 
Collection

Coagulation

Chemistry, Central Lab Sorrento Mesa                                                       Updated:  04/19/2023
 

Collect

SST (Min Vol 1 mL)

**NOT for maternal serum or amniotic fluid**
 

Storage/Transport Temperature

Transport refrigerated (2-8°C)
 

Stability (from collection to initiation)

Room temperature:  3 days
Refrigerated:  7 days
Frozen  -20°C or colder Aliquot:  for longer storage

Avoid more than 5 freeze/thaw cycle
 

Performed

Daily
Ordering

Ordering Recommendations

The Alinity i AFP assay is a chemiluminescent microparticle immunoassay (CMIA) used for the quantitative determination of alpha-fetoprotein (AFP) on the Alinity i analyzer in human serum to aid in monitoring disease progression during the course of disease and treatment of patients with nonseminomatous testicular cancer.

Methodology

Abbott – Alinity
Methodology: Chemiluminescent microparticle immunoassay (CMIA)

Synonyms

  • Alpha-Fetoprotein
  • LAB559
  • AFP

Notes

Limitations of the procedure:

• If the AFP results are inconsistent with clinical evidence, additional testing is suggested to confirm the result.
• For diagnostic purposes, results should be used in conjunction with other data; e.g., symptoms, results of other tests, clinical impressions, etc.
• Specimens from patients who have received preparations of mouse monoclonal antibodies for diagnosis or therapy may contain human anti-mouse antibodies (HAMA). Specimens
containing HAMA may produce anomalous values when tested with assay kits such as Alinity i AFP that employ mouse monoclonal antibodies.
• Heterophilic antibodies in human serum can react with reagent immunoglobulins, interfering with in vitro immunoassays. Patients routinely exposed to animals or to animal serum products can be prone to this interference and anomalous results may be observed. Additional information may be required for diagnosis.
• Although the Alinity i AFP assay is specifically designed to minimize the effects of HAMA and heterophilic antibodies, assay results that are not consistent with other clinical observations may require additional information for diagnosis.
• The Alinity i AFP assay is a valuable aid in the management of nonseminomatous testicular cancer patients when used in conjunction with information available from the clinical evaluation and other diagnostic procedures. Increased serum AFP concentrations have also been observed in ataxia telangiectasia, hereditary tyrosinemia, primary hepatocellular carcinoma, teratocarcinoma, gastrointestinal tract cancers with and without liver metastases and in benign hepatic conditions such as acute viral hepatitis, chronic active hepatitis and cirrhosis.
• The Alinity i AFP assay should not be used as a cancer screening test.

Specimens get discarded after 7 days

 
Result Interpretation

Reference Interval

0 up to 1 Months: >2,000.00 ng/mL

1 Months up to 6 Months: 10.00-1,359.00 ng/mL

6 Months up to 1 Years: 0.00-103.00 ng/mL

1 Years up to 19 Years: 2.00-35.00 ng/mL

19 Years up to Unspecified: 2.00-8.78 ng/mL
Administrative

CPT Codes

82105
 

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