Internal Samples: Transport EDTA tubes to Metabolic lab at room temperature.
External Samples: WBC pellets from EDTA blood samples should be separated at the source, frozen and shipped on dry ice.
Stability (from collection to initiation)
Internal: EDTA tubes can be stored at 4°C for 24 hours prior to arrival in Metabolic lab.
External: WBC pellets stored at -80°C are stable for 3 months.
Volume Required
4 mL
Minimum Required
2 mL
Phlebotomy Draw
Yes
Collection Times
On Fridays or the day before a holiday, call the Metabolic lab at 215-590-3394 prior to draw.
Performing Lab
Metabolic Lab
Performed
Every 2 Weeks
Methodology
UPLC
Reported
14 days
Synonyms
Coenzyme Q10
Leukocyte Coenzyme Q
Leukocyte CoQ10
WBC Q10
Coenzyme Q
Available STAT
No
Interpretive Data
The levels of coenzyme Q10 in leukocytes correlate with muscle coenzyme Q10 levels, Low levels of Coenzyme Q10 can be seen as a secondary finding in patients with mitochondrial oxidative phosphorylation defects and patients treated with statin therapy. It can also be seen as a primary deficiency in patients with pathogenic variants affecting coenzyme Q10 biosynthesis. Coenzyme Q10 levels are serially tracked in patients on coenzyme Q10 therapy to ensure the levels are normal or high, consistent with therapeutic efficacy.
Reference Ranges
136 - 247 pmol/mg protein of WBC
CPT Codes
82542
Billing (EAP) Codes
803336
Interpretive Data
The levels of coenzyme Q10 in leukocytes correlate with muscle coenzyme Q10 levels, Low levels of Coenzyme Q10 can be seen as a secondary finding in patients with mitochondrial oxidative phosphorylation defects and patients treated with statin therapy. It can also be seen as a primary deficiency in patients with pathogenic variants affecting coenzyme Q10 biosynthesis. Coenzyme Q10 levels are serially tracked in patients on coenzyme Q10 therapy to ensure the levels are normal or high, consistent with therapeutic efficacy.
Collection
Collect
EDTA (purple) tube
Unacceptable Conditions
Hemolyzed,
>24 hours at room temperature
Storage/Transport Temperature
Internal Samples: Transport EDTA tubes to Metabolic lab at room temperature.
External Samples: WBC pellets from EDTA blood samples should be separated at the source, frozen and shipped on dry ice.
Stability (from collection to initiation)
Internal: EDTA tubes can be stored at 4°C for 24 hours prior to arrival in Metabolic lab.
External: WBC pellets stored at -80°C are stable for 3 months.
Volume Required
4 mL
Minimum Required
2 mL
Phlebotomy Draw
Yes
Collection Times
On Fridays or the day before a holiday, call the Metabolic lab at 215-590-3394 prior to draw.
Ordering
Performing Lab
Metabolic Lab
Performed
Every 2 Weeks
Methodology
UPLC
Reported
14 days
Synonyms
Coenzyme Q10
Leukocyte Coenzyme Q
Leukocyte CoQ10
WBC Q10
Coenzyme Q
Available STAT
No
Result Interpretation
Interpretive Data
The levels of coenzyme Q10 in leukocytes correlate with muscle coenzyme Q10 levels, Low levels of Coenzyme Q10 can be seen as a secondary finding in patients with mitochondrial oxidative phosphorylation defects and patients treated with statin therapy. It can also be seen as a primary deficiency in patients with pathogenic variants affecting coenzyme Q10 biosynthesis. Coenzyme Q10 levels are serially tracked in patients on coenzyme Q10 therapy to ensure the levels are normal or high, consistent with therapeutic efficacy.
Reference Ranges
136 - 247 pmol/mg protein of WBC
Administrative
CPT Codes
82542
Billing (EAP) Codes
803336
Interpretive Data
The levels of coenzyme Q10 in leukocytes correlate with muscle coenzyme Q10 levels, Low levels of Coenzyme Q10 can be seen as a secondary finding in patients with mitochondrial oxidative phosphorylation defects and patients treated with statin therapy. It can also be seen as a primary deficiency in patients with pathogenic variants affecting coenzyme Q10 biosynthesis. Coenzyme Q10 levels are serially tracked in patients on coenzyme Q10 therapy to ensure the levels are normal or high, consistent with therapeutic efficacy.
