Remove serum from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube and freeze. (Min: 0.5 mL)
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Stability (from collection to initiation)
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
Performed
Mon, Thu
Notes
Circulating antibodies in patient's serum are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of a normal control population are interpreted as "weakly positive" and greater than 3 standard deviations as "positive".
This test should not be confused with Anti-Neutrophil Cytoplasmic Antibody, IgG (0050811 - ANCA).
Collect
Plain red or serum separator tube.
Ordering Recommendations
Support the diagnosis of immune neutropenia in various autoimmune disorders.
Neutrophil-associated antibodies may cause neutropenia in various autoimmune disorders including Felty syndrome, SLE and drug-induced neutropenia. Febrile transfusion reactions and isoimmune neonatal neutropenia may also be caused by antibodies to neutrophil-specific antigens or HLA antigens.
A positive result on this test is not definitive for specific antineutrophil antibodies, since anti-HLA antibodies and immune complexes may also cause a positive result. The results of this test should be correlated to clinical history and other data.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
CPT Codes
86021
LOINC
41617-2
ARUP Test Code
0055506
Collection
Collect
Plain red or serum separator tube.
Specimen Preparation
Remove serum from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube and freeze. (Min: 0.5 mL)
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Stability (from collection to initiation)
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
Performed
Mon, Thu
Notes
Circulating antibodies in patient's serum are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of a normal control population are interpreted as "weakly positive" and greater than 3 standard deviations as "positive".
This test should not be confused with Anti-Neutrophil Cytoplasmic Antibody, IgG (0050811 - ANCA).
Container
Collect
Plain red or serum separator tube.
Ordering
Ordering Recommendations
Support the diagnosis of immune neutropenia in various autoimmune disorders.
Neutrophil-associated antibodies may cause neutropenia in various autoimmune disorders including Felty syndrome, SLE and drug-induced neutropenia. Febrile transfusion reactions and isoimmune neonatal neutropenia may also be caused by antibodies to neutrophil-specific antigens or HLA antigens.
A positive result on this test is not definitive for specific antineutrophil antibodies, since anti-HLA antibodies and immune complexes may also cause a positive result. The results of this test should be correlated to clinical history and other data.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
