Collect

Plain red or serum separator tube.

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Performed

Varies

Remarks

As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.

Referral Lab

Laboratories.

Ordering Recommendations

Use to assess and monitor pemphigoid, pemphigoid variants, and linear IgA disease and to discriminate among the immunobullous diseases with epithelial basement membrane zone antibodies. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Preferred initial diagnostic serum panel is Basement Membrane Zone Antibody Panel (3001410). Bullous pemphigoid and other pemphigoid variants, epidermolysis bullosa acquisita (EBA), linear IgA disease, and dermatitis herpetiformis may present with similar clinical findings including blistering, erosions, pruritus, and urticaria, which affect skin and mucous membranes. To assess for other immunobullous diseases with diagnostic serum epithelial antibodies in addition to pemphigoid, order concurrently with Pemphigus Antibody Panel, IgG (0090650) and Collagen Type VII Antibody, IgG by ELISA (2010905). Alternatively, order Immunobullous Disease Antibody Panel (3001409). For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

Performed

Varies

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Reported

4-9 days after receipt at reference laboratory

Synonyms

  • Bullous Pemphigoid
  • salt-split skin roof antibodies
  • salt-split skin test
  • subepithelial immunobullous disease
  • type XVII collagen
  • basement membrane zone antibody-associated disease
  • bullous disease of childhood
  • bullous lupus erythematosus
  • bullous pemphigoid antigen 1 or BPAg1
  • bullous pemphigoid antigen 2 or BPAg2
  • childhood immunobullous disease
  • chronic bullous disease of childhood
  • cicatricial pemphigoid
  • collagen type 17
  • collagen type XVII
  • dermal basement membrane zone antibodies on split skin substrate
  • epidermal basement membrane zone antibodies on split skin substrate
  • epidermolysis bullosa acquisita
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • IgA variant epidermolysis bullosa acquisita (EBA)
  • IgG/IgA basement membrane zone antibodies
  • immunobullous disease of childhood
  • linear IgA bullous dermatosis
  • linear IgA disease
  • linear IgG/IgA bullous dermatosis
  • mixed immunobullous disease of childhood
  • mucous membrane pemphigoid
  • NC16A
  • ocular cicatricial pemphigoid
  • Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP2
  • pemphigoid variants
  • salt-split skin floor antibodies
  • IgG and IgA, BP180 and BP230
  • bullous pemphigoid antigen 2 or BPAg2, NC16A
  • bullous systemic lupus erythematosus
  • Brunsting-Perry cicatricial pemphigoid
  • dermal basement membrane zone (floor) antibodies with split skin substrate
  • epidermal basement membrane zone (roof) antibodies with split skin substrate
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • linear IgA/IgG bullous dermatosis
  • atypical epithelial antibody-associated disease
  • Brunsting-Perry pemphigoid
  • mixed epithelial antibody-associated disease
  • epidermolysis bullosa acquisita (EBA)
  • epithelial antibody-associated disease
  • IgA mucous membrane pemphigoid
  • Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies

Notes

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Reference Interval

By report

Interpretive Data

Refer to report.

CPT Codes

88346; 88350 x3; 83516 x2

ARUP Test Code

0092001

LOINC

  • 48767-8
  • 11526-1

Performing Lab

ARUP Laboratories

Interfaced Client/Test Mapping

Mapping - Pending
Order Order code Result Result Code AOE Prompt Prompt Code Prompt Response Response Code
               
               
Collection

Collect

Plain red or serum separator tube.

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Performed

Varies

Remarks

As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.

Referral Lab

Laboratories.
Ordering

Ordering Recommendations

Use to assess and monitor pemphigoid, pemphigoid variants, and linear IgA disease and to discriminate among the immunobullous diseases with epithelial basement membrane zone antibodies. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Preferred initial diagnostic serum panel is Basement Membrane Zone Antibody Panel (3001410). Bullous pemphigoid and other pemphigoid variants, epidermolysis bullosa acquisita (EBA), linear IgA disease, and dermatitis herpetiformis may present with similar clinical findings including blistering, erosions, pruritus, and urticaria, which affect skin and mucous membranes. To assess for other immunobullous diseases with diagnostic serum epithelial antibodies in addition to pemphigoid, order concurrently with Pemphigus Antibody Panel, IgG (0090650) and Collagen Type VII Antibody, IgG by ELISA (2010905). Alternatively, order Immunobullous Disease Antibody Panel (3001409). For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

Performed

Varies

Methodology

Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Reported

4-9 days after receipt at reference laboratory

Synonyms

  • Bullous Pemphigoid
  • salt-split skin roof antibodies
  • salt-split skin test
  • subepithelial immunobullous disease
  • type XVII collagen
  • basement membrane zone antibody-associated disease
  • bullous disease of childhood
  • bullous lupus erythematosus
  • bullous pemphigoid antigen 1 or BPAg1
  • bullous pemphigoid antigen 2 or BPAg2
  • childhood immunobullous disease
  • chronic bullous disease of childhood
  • cicatricial pemphigoid
  • collagen type 17
  • collagen type XVII
  • dermal basement membrane zone antibodies on split skin substrate
  • epidermal basement membrane zone antibodies on split skin substrate
  • epidermolysis bullosa acquisita
  • hemidesmosomal protein antibodies
  • hemidesmosome antibodies
  • IgA variant epidermolysis bullosa acquisita (EBA)
  • IgG/IgA basement membrane zone antibodies
  • immunobullous disease of childhood
  • linear IgA bullous dermatosis
  • linear IgA disease
  • linear IgG/IgA bullous dermatosis
  • mixed immunobullous disease of childhood
  • mucous membrane pemphigoid
  • NC16A
  • ocular cicatricial pemphigoid
  • Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP2
  • pemphigoid variants
  • salt-split skin floor antibodies
  • IgG and IgA, BP180 and BP230
  • bullous pemphigoid antigen 2 or BPAg2, NC16A
  • bullous systemic lupus erythematosus
  • Brunsting-Perry cicatricial pemphigoid
  • dermal basement membrane zone (floor) antibodies with split skin substrate
  • epidermal basement membrane zone (roof) antibodies with split skin substrate
  • indirect fluorescence assay
  • indirect fluorescent antibody (IFA)
  • indirect immunofluorescent assay
  • linear IgA/IgG bullous dermatosis
  • atypical epithelial antibody-associated disease
  • Brunsting-Perry pemphigoid
  • mixed epithelial antibody-associated disease
  • epidermolysis bullosa acquisita (EBA)
  • epithelial antibody-associated disease
  • IgA mucous membrane pemphigoid
  • Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies

Notes

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.
Result Interpretation

Reference Interval

By report

Interpretive Data

Refer to report.

Administrative

CPT Codes

88346; 88350 x3; 83516 x2

ARUP Test Code

0092001

LOINC

  • 48767-8
  • 11526-1

Performing Lab

ARUP Laboratories

Interfaced Client/Test Mapping

Mapping - Pending
Order Order code Result Result Code AOE Prompt Prompt Code Prompt Response Response Code
               
               

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