Ordering Recommendations

This test detects CMV DNA in specimens other than CSF or Blood (see acceptable specimens below).  This test may be useful in monitoring disease progression and/or response to therapy.
For testing CSF, order Test Code: MENCP
For testing Blood, order Test Code: CMVQ

Collection Instructions

Saliva is the recommended specimen when testing for Congenital CMV disease in neonates < 21 days old; a positive test with saliva requires testing of a urine specimen as confirmation within the first 3 weeks of life.  Urine is the only acceptable specimen when testing for Congenital CMV disease in ages > 21 days old.

Neonatal saliva specimens: Use Orange-capped Copan flocked swab.  Wait at least 1 hour after the consumption of breast milk before sample collection.  To collect, place orange capped Copan flocked swab in baby's mouth along cheek to absorb saliva and then place swab in transport tube.

Conjunctival eye swab: Use flocked swab and submit in UTM
Vitreous and Aqueous Eye Fluid: Submit fluid in syringe.
Urine, Amniotic Fluid, BAL, Bronch Wash, Tracheal Aspirate, Tracheal Wash, Tissues: Submit specimen in sterile container.
Bone marrow: Submit specimen in EDTA vacutainer tube.

Storage/Transport Temperature

Transport specimens other than urine to laboratory at room temperature.  Transport Urine on cold packs.

Unacceptable Conditions

Whole blood frozen, specimens greater than 96 hours old, or specimen types other than those listed  For neonate saliva specimens: not an orange-capped copan flocked swab, patients > 21 days old.

Remarks

CMV is an important pathogen in the transplant setting causing pneumonitis, colitis, hepatitis, CNS disease, neutropenia, and disseminated disease. Prior to the availability of rapid and sensitive DNA PCR, CMV was a leading cause of morbidity and mortality in the transplant population. Quantitative CMV DNA PCR can be used for early detection of CMV reactivation, primary infections, and monitoring response to treatment.

CMV testing for neonates should only be ordered for neonate patients who fail the initial hearing screen.

Stability (from collection to initiation)

Neonatal saliva: Ambient for 48 hours; Refrigerated: 7 days
Urine, BAL, Bronch Wash, Tracheal Aspirate, Tracheal Wash, Eye swabs, Amniotic fluid, Pleural fluid, Pericardial fluid, Bone Marrow: Ambient: 96 hours
CSF, aqueous and vitreous fluids, tissues, stool: Frozen: 96 hours
Urine: Refrigerated: 3 days

Alternate Specimen Requirements

Less commonly, respiratory and GI specimens also acceptable.  Please contact the Virology laboratory at 758-0513

Lab Section

Microbiology (Virology)

Methodology

Nucleic Acid Amplification

Performed

Mon-Fri
Testing on CMV saliva samples performed daily.

Reported

2 - 4 days
CMV saliva testing results reported within 24 hours

Performing Laboratory Website (click below)

UR Medicine Labs - for neonate saliva specimens
www.eurofins-viracor.com - all other non-blood specimens

Reference Interval

Not detected

Interpretive Data

See report for specific assay ranges

CPT Codes

Quantitative 87497
Qualitative 87496

Order Type (Individual or Group)

I

Result Test ID

CMVQT

Result Test Name

CMV DNA PCR (NON-BLOOD)

Result Type (Individual or Group)

I

Type (Alpha or Numeric)

A

Default Result

See Micro

Text

Saliva (Infants <21 days) NOTE: Wait at least two hours after the consumption of  breast milk before sample collection

Micro Source Information

 
Source ID             Source Name Sites REFLEX TESTS
AMNIO AMNIOTIC FLUID    
AQFL AQUEOUS FLUID    
BAL BRONCHIAL ALVEOLAR LAVAGE RIGHT UPPER LOBE
RIGHT MIDDLE LOBE
RIGHT LOWER LOBE
LEFT UPPER LOBE
LEFT MIDDLE LOBE		  
BM BOME MARROW    
BW BRONCHIAL WASH    
BA BRONCHIAL ASPIRATE    
CONJ CONJUNCTIVA LEFT 
RIGHT		  
EYE EYE LEFT
RIGHT		  
SALN SALIVA (INFANTS <21 DAYS)    
STOOL STOOL    
TA TRACHEAL ASPIRATE    
TISSU TISSUE    
UCATH URINE (CATHETER)    
URINE URINE CLEAN CATCH
MIDSTREAM
VOIDED		  
VITF VITREOUS FLUID    

CPT Codes

Quantitative 87497
Qualitative 87496

Pricing

Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu
Specimen Requirements

Ordering Recommendations

This test detects CMV DNA in specimens other than CSF or Blood (see acceptable specimens below).  This test may be useful in monitoring disease progression and/or response to therapy.
For testing CSF, order Test Code: MENCP
For testing Blood, order Test Code: CMVQ

Collection Instructions

Saliva is the recommended specimen when testing for Congenital CMV disease in neonates < 21 days old; a positive test with saliva requires testing of a urine specimen as confirmation within the first 3 weeks of life.  Urine is the only acceptable specimen when testing for Congenital CMV disease in ages > 21 days old.

Neonatal saliva specimens: Use Orange-capped Copan flocked swab.  Wait at least 1 hour after the consumption of breast milk before sample collection.  To collect, place orange capped Copan flocked swab in baby's mouth along cheek to absorb saliva and then place swab in transport tube.

Conjunctival eye swab: Use flocked swab and submit in UTM
Vitreous and Aqueous Eye Fluid: Submit fluid in syringe.
Urine, Amniotic Fluid, BAL, Bronch Wash, Tracheal Aspirate, Tracheal Wash, Tissues: Submit specimen in sterile container.
Bone marrow: Submit specimen in EDTA vacutainer tube.

Storage/Transport Temperature

Transport specimens other than urine to laboratory at room temperature.  Transport Urine on cold packs.

Unacceptable Conditions

Whole blood frozen, specimens greater than 96 hours old, or specimen types other than those listed  For neonate saliva specimens: not an orange-capped copan flocked swab, patients > 21 days old.

Remarks

CMV is an important pathogen in the transplant setting causing pneumonitis, colitis, hepatitis, CNS disease, neutropenia, and disseminated disease. Prior to the availability of rapid and sensitive DNA PCR, CMV was a leading cause of morbidity and mortality in the transplant population. Quantitative CMV DNA PCR can be used for early detection of CMV reactivation, primary infections, and monitoring response to treatment.

CMV testing for neonates should only be ordered for neonate patients who fail the initial hearing screen.

Stability (from collection to initiation)

Neonatal saliva: Ambient for 48 hours; Refrigerated: 7 days
Urine, BAL, Bronch Wash, Tracheal Aspirate, Tracheal Wash, Eye swabs, Amniotic fluid, Pleural fluid, Pericardial fluid, Bone Marrow: Ambient: 96 hours
CSF, aqueous and vitreous fluids, tissues, stool: Frozen: 96 hours
Urine: Refrigerated: 3 days

Alternate Specimen Requirements

Less commonly, respiratory and GI specimens also acceptable.  Please contact the Virology laboratory at 758-0513
Testing

Lab Section

Microbiology (Virology)

Methodology

Nucleic Acid Amplification

Performed

Mon-Fri
Testing on CMV saliva samples performed daily.

Reported

2 - 4 days
CMV saliva testing results reported within 24 hours

Performing Laboratory Website (click below)

UR Medicine Labs - for neonate saliva specimens
www.eurofins-viracor.com - all other non-blood specimens

Result Interpretation

Reference Interval

Not detected

Interpretive Data

See report for specific assay ranges
Coding

CPT Codes

Quantitative 87497
Qualitative 87496
URM Labs Internal
Test Build

Order Type (Individual or Group)

I

Result Test ID

CMVQT

Result Test Name

CMV DNA PCR (NON-BLOOD)

Result Type (Individual or Group)

I

Type (Alpha or Numeric)

A

Default Result

See Micro

Text

Saliva (Infants <21 days) NOTE: Wait at least two hours after the consumption of  breast milk before sample collection

Micro Source Information

 
Source ID             Source Name Sites REFLEX TESTS
AMNIO AMNIOTIC FLUID    
AQFL AQUEOUS FLUID    
BAL BRONCHIAL ALVEOLAR LAVAGE RIGHT UPPER LOBE
RIGHT MIDDLE LOBE
RIGHT LOWER LOBE
LEFT UPPER LOBE
LEFT MIDDLE LOBE		  
BM BOME MARROW    
BW BRONCHIAL WASH    
BA BRONCHIAL ASPIRATE    
CONJ CONJUNCTIVA LEFT 
RIGHT		  
EYE EYE LEFT
RIGHT		  
SALN SALIVA (INFANTS <21 DAYS)    
STOOL STOOL    
TA TRACHEAL ASPIRATE    
TISSU TISSUE    
UCATH URINE (CATHETER)    
URINE URINE CLEAN CATCH
MIDSTREAM
VOIDED		  
VITF VITREOUS FLUID    

CPT Codes

Quantitative 87497
Qualitative 87496

Pricing

Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu

Important Information

Lab Section
Microbiology (Virology)

ARUP Consult®

Disease Topics

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