Assessment of clinical activity of and initial diagnostic testing for myasthenia gravis. For reflexive panel, which contains binding, blocking, and modulating antibodies, refer to Acetylcholine Receptor Antibody Reflexive Panel (2001571).
Collect
Serum Separator Tube (SST).
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Contaminated, hemolyzed, or severely lipemic specimens.
Stability (from collection to initiation)
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Approximately 85-90 percent of patients with myasthenia gravis (MG) express antibodies to the acetylcholine receptor (AChR), which can be divided into binding, blocking, and modulating antibodies. Binding antibody can activate complement and lead to loss of AChR. Blocking antibody may impair binding of acetylcholine to the receptor, leading to poor muscle contraction. Modulating antibody causes receptor endocytosis resulting in loss of AChR expression, which correlates most closely with clinical severity of disease. Approximately 10-15 percent of individuals with confirmed myasthenia gravis have no measurable binding, blocking, or modulating antibodies.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Component
Interpretation
Acetylcholine Receptor Modulating Antibody
Negative: 0-45% modulating Positive: 46% or greater modulating
CPT Codes
86043
LOINC
30192-9
Order Type (Individual or Group)
I
Result Test ID
ACRM
Reportable?
Y
Result Test Name
ACETYLCHOLINE REC MOD AB
Result Type (Individual or Group)
I
Type (Alpha or Numeric)
N
Text
SEPARATE FROM CELLS WITHIN 2 HOURS
CPT Codes
86043
LOINC
30192-9
Pricing
Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu
Specimen Requirements
Ordering Recommendations
Assessment of clinical activity of and initial diagnostic testing for myasthenia gravis. For reflexive panel, which contains binding, blocking, and modulating antibodies, refer to Acetylcholine Receptor Antibody Reflexive Panel (2001571).
Collect
Serum Separator Tube (SST).
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Contaminated, hemolyzed, or severely lipemic specimens.
Stability (from collection to initiation)
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Approximately 85-90 percent of patients with myasthenia gravis (MG) express antibodies to the acetylcholine receptor (AChR), which can be divided into binding, blocking, and modulating antibodies. Binding antibody can activate complement and lead to loss of AChR. Blocking antibody may impair binding of acetylcholine to the receptor, leading to poor muscle contraction. Modulating antibody causes receptor endocytosis resulting in loss of AChR expression, which correlates most closely with clinical severity of disease. Approximately 10-15 percent of individuals with confirmed myasthenia gravis have no measurable binding, blocking, or modulating antibodies.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Component
Interpretation
Acetylcholine Receptor Modulating Antibody
Negative: 0-45% modulating Positive: 46% or greater modulating
Coding
CPT Codes
86043
LOINC
30192-9
URM Labs Internal
Test Build
Order Type (Individual or Group)
I
Result Test ID
ACRM
Reportable?
Y
Result Test Name
ACETYLCHOLINE REC MOD AB
Result Type (Individual or Group)
I
Type (Alpha or Numeric)
N
Text
SEPARATE FROM CELLS WITHIN 2 HOURS
CPT Codes
86043
LOINC
30192-9
Pricing
Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu
Important Information
Lab Section
Send-out Lab
Restricted Test Information
RESTRICTED TEST: This test is restricted to board-certified, subspecialty trained physicians with Staff Privileges at Strong Memorial Hospital, Highland Hospital or F.F. Thompson Hospital. For exceptions: Please refer to the LDC Appeal Process.
Laboratories.