Ordering Recommendations

First-line test in suspected pheochromocytoma.

Patient Preparation

If possible, abstain from medications for 72 hours prior to collection.

Collection Instructions

Specimen can be collected in plain container or container with 6N HCl preservative.

Collect

24-hour or random urine. Refrigerate 24-hour specimen during collection.

Specimen Preparation

Thoroughly mix entire collection (24-hour or random) in one container. Transfer a 4 mL aliquot to an ARUP standard transport tube. (Min: 2.5 mL) A pH lower than 2 can cause assay interference. Record total volume and collection time interval on transport tube and test request form.
Specimen preservation can be extended to 1 month refrigerated by performing one of the following:
  Option 1: Transfer a 4 mL aliquot to an ARUP standard transport tube. (Min: 2.5 mL) Adjust pH to 2.0-4.0 with 6M HCl.
  Option 2: Transfer a 4 mL aliquot to an ARUP standard transport tube containing 20 mg sulfamic acid (ARUP Supply #48098), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787. (Min: 2.5 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Specimens preserved with boric acid or acetic acid.

Stability (from collection to initiation)

Ambient: Unacceptable; Refrigerated: 2 weeks (unpreserved), 1 month (preserved); Frozen: 1 month

Test Barcode Number

21853

Referral Lab

Laboratories.

Lab Section

Send-Out Lab

Performing Lab

ARUP Laboratories

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-5 days

Synonyms

  • 2007996

Reference Interval

Components
Reference Interval
Creatinine, Urine - per 24h
Age
Male (mg/d)
Female (mg/d)
3-8 years140-700140-700
9-12 years300-1300300-1300
13-17 years500-2300400-1600
18-50 years1000-2500700-1600
51-80 years800-2100500-1400
81 years and older600-2000400-1300

Metanephrine, Urine - per 24h
AgeMale (µg/d)Female (µg/d)
0-6 yearsNot ApplicableNot Applicable
7-12 years45-27340-209
13-17 years56-29840-209
18 years and older55-32036-229

Metanephrine, Urine - ratio to CRT
Ageµg/g CRT
0-3 months0-700
4-6 months0-650
7-11 months0-650
1 year0-530
2-5 years0-500
6-17 years0-320
18 years and older0-300

Normetanephrine, Urine - per 24h
AgeMale (µg/d)Female (µg/d)
0-6 yearsNot ApplicableNot Applicable
7-12 years58-67048-474
13-17 years82-55365-406
18-29 years81-66718 years and older: 95-650
30 years and older114-865Not Applicable

Normetanephrine, Urine - ratio to CRT
Ageµg/g CRT
0-3 months0-3400
4-6 months0-2200
7-11 months0-1100
1 year0-1300
2-5 years0-610
6-17 years0-450
18 years and older0-400


Interpretive Data

Smaller increases in metanephrine and/or normetanephrine concentrations (less than two times the upper reference limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Essential hypertension is often associated with slight elevations (metanephrine less than 400 ug/d and normetanephrine less than 900 ug/d). Elevated concentrations may be due to intense physical activity, life-threatening illness, and drug interferences.

Significant elevation of one or both metanephrines (three or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor. 

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

CPT Codes

83835

LOINC

  • 35674-1
  • 2162-6
  • 49283-5
  • 19153-6
  • 30211-7
  • 21019-5
  • 21422-1
  • 19049-6
  • 35644-4
  • 2671-6
  • 44342-4

Order Type (Individual or Group)

G

Group Test Information

Result Test ID Reportable Result Test Name Result Type Type (Alpha or Numeric) Prompt Test
TIME Y COLLECTION PERIOD I N  
UVOLU Y TOTAL VOLUME,UR I N  
METAN Y METANEPHRINES I N  
METAV Y METANEPHRINE PER VOLUME I A  
METCR Y METANEPHRINE/CREAT I A  
NOTA Y NORMETANEPHRINE I N  
NORMV Y NORMETANEPHRINE PER VOLUME I A  
NOTCR Y NORMETANEPHRINE/CREAT I A  
METIN Y METANEPHRINE INTERP,UR I A  
CRR Y CREATININE,UR I A  
CR24 Y CREATININE/24,UR I A  
TVPRO Y TIMED URINE PROFILE G https://www.testmenu.com/rochester/Tests/1090948 O

Text

COLLECT IN CONTAINER WITH PRESERVATIVE    

CPT Codes

83835

LOINC

  • 35674-1
  • 2162-6
  • 49283-5
  • 19153-6
  • 30211-7
  • 21019-5
  • 21422-1
  • 19049-6
  • 35644-4
  • 2671-6
  • 44342-4

Pricing

Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu
Specimen Requirements

Ordering Recommendations

First-line test in suspected pheochromocytoma.

Patient Preparation

If possible, abstain from medications for 72 hours prior to collection.

Collection Instructions

Specimen can be collected in plain container or container with 6N HCl preservative.

Collect

24-hour or random urine. Refrigerate 24-hour specimen during collection.

Specimen Preparation

Thoroughly mix entire collection (24-hour or random) in one container. Transfer a 4 mL aliquot to an ARUP standard transport tube. (Min: 2.5 mL) A pH lower than 2 can cause assay interference. Record total volume and collection time interval on transport tube and test request form.
Specimen preservation can be extended to 1 month refrigerated by performing one of the following:
  Option 1: Transfer a 4 mL aliquot to an ARUP standard transport tube. (Min: 2.5 mL) Adjust pH to 2.0-4.0 with 6M HCl.
  Option 2: Transfer a 4 mL aliquot to an ARUP standard transport tube containing 20 mg sulfamic acid (ARUP Supply #48098), available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787. (Min: 2.5 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions

Specimens preserved with boric acid or acetic acid.

Stability (from collection to initiation)

Ambient: Unacceptable; Refrigerated: 2 weeks (unpreserved), 1 month (preserved); Frozen: 1 month

Test Barcode Number

21853

Referral Lab

Laboratories.
Testing

Lab Section

Send-Out Lab

Performing Lab

ARUP Laboratories

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-5 days

Synonyms

  • 2007996
Result Interpretation

Reference Interval

Components
Reference Interval
Creatinine, Urine - per 24h
Age
Male (mg/d)
Female (mg/d)
3-8 years140-700140-700
9-12 years300-1300300-1300
13-17 years500-2300400-1600
18-50 years1000-2500700-1600
51-80 years800-2100500-1400
81 years and older600-2000400-1300

Metanephrine, Urine - per 24h
AgeMale (µg/d)Female (µg/d)
0-6 yearsNot ApplicableNot Applicable
7-12 years45-27340-209
13-17 years56-29840-209
18 years and older55-32036-229

Metanephrine, Urine - ratio to CRT
Ageµg/g CRT
0-3 months0-700
4-6 months0-650
7-11 months0-650
1 year0-530
2-5 years0-500
6-17 years0-320
18 years and older0-300

Normetanephrine, Urine - per 24h
AgeMale (µg/d)Female (µg/d)
0-6 yearsNot ApplicableNot Applicable
7-12 years58-67048-474
13-17 years82-55365-406
18-29 years81-66718 years and older: 95-650
30 years and older114-865Not Applicable

Normetanephrine, Urine - ratio to CRT
Ageµg/g CRT
0-3 months0-3400
4-6 months0-2200
7-11 months0-1100
1 year0-1300
2-5 years0-610
6-17 years0-450
18 years and older0-400


Interpretive Data

Smaller increases in metanephrine and/or normetanephrine concentrations (less than two times the upper reference limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Essential hypertension is often associated with slight elevations (metanephrine less than 400 ug/d and normetanephrine less than 900 ug/d). Elevated concentrations may be due to intense physical activity, life-threatening illness, and drug interferences.

Significant elevation of one or both metanephrines (three or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor. 

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

Coding

CPT Codes

83835

LOINC

  • 35674-1
  • 2162-6
  • 49283-5
  • 19153-6
  • 30211-7
  • 21019-5
  • 21422-1
  • 19049-6
  • 35644-4
  • 2671-6
  • 44342-4
URM Labs Internal
Test Build

Order Type (Individual or Group)

G

Group Test Information

Result Test ID Reportable Result Test Name Result Type Type (Alpha or Numeric) Prompt Test
TIME Y COLLECTION PERIOD I N  
UVOLU Y TOTAL VOLUME,UR I N  
METAN Y METANEPHRINES I N  
METAV Y METANEPHRINE PER VOLUME I A  
METCR Y METANEPHRINE/CREAT I A  
NOTA Y NORMETANEPHRINE I N  
NORMV Y NORMETANEPHRINE PER VOLUME I A  
NOTCR Y NORMETANEPHRINE/CREAT I A  
METIN Y METANEPHRINE INTERP,UR I A  
CRR Y CREATININE,UR I A  
CR24 Y CREATININE/24,UR I A  
TVPRO Y TIMED URINE PROFILE G https://www.testmenu.com/rochester/Tests/1090948 O

Text

COLLECT IN CONTAINER WITH PRESERVATIVE    

CPT Codes

83835

LOINC

  • 35674-1
  • 2162-6
  • 49283-5
  • 19153-6
  • 30211-7
  • 21019-5
  • 21422-1
  • 19049-6
  • 35644-4
  • 2671-6
  • 44342-4

Pricing

Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu

Important Information

Lab Section

Send-Out Lab

ARUP Consult®

Disease Topics

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