If pursuing antibody testing to determine autoimmune diabetes mellitus (DM), perform at least two antibody tests. In most cases, use glutamic acid decarboxylase antibody in combination with another antibody test. Other antibody tests include Islet Antigen-2 (IA-2) Autoantibody (3001499), Glutamic Acid Decarboxylase Antibody (2001771), Insulin Antibody (0099228), and Zinc Transporter 8 Antibody (2006196). Most useful to establish autoimmune etiology in previously diagnosed type 1 DM. Do not use to differentiate type 1 DM from type 2 DM, for most cases.
Collect
Serum separator tube.
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer1 mL serum to an ARUP standard transport tube. (Min: 0.50 mL)
Unacceptable Conditions
Plasma. CSF. Contaminated, hemolyzed, or severely lipemic specimens.
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month.
Islet cell antibodies (ICAs) are associated with type 1 diabetes (T1D), an autoimmune endocrine disorder. ICAs may be present years before the onset of clinical symptoms. To calculate Juvenile Diabetes Foundation (JDF) units: multiply the titer x 5 (1:8 8 x 5 = 40 JDF Units).
CPT Codes
86341
LOINC
13927-9
Performing Lab
ARUP Laboratories
Collection
Synonyms
Anti-Islet Cell Antibody, IgG
Islet Cell Cytoplasmic Ab IgG
Cytoplasmic Islet Cell Ab
Anti-Islet Cell Antibody
beta cell
ICA
Islet Cell Ab IgG
Performed
Sun-Sat
Reported
1-3 days
Ordering Recommendations
If pursuing antibody testing to determine autoimmune diabetes mellitus (DM), perform at least two antibody tests. In most cases, use glutamic acid decarboxylase antibody in combination with another antibody test. Other antibody tests include Islet Antigen-2 (IA-2) Autoantibody (3001499), Glutamic Acid Decarboxylase Antibody (2001771), Insulin Antibody (0099228), and Zinc Transporter 8 Antibody (2006196). Most useful to establish autoimmune etiology in previously diagnosed type 1 DM. Do not use to differentiate type 1 DM from type 2 DM, for most cases.
Collect
Serum separator tube.
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer1 mL serum to an ARUP standard transport tube. (Min: 0.50 mL)
Unacceptable Conditions
Plasma. CSF. Contaminated, hemolyzed, or severely lipemic specimens.
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month.
Islet cell antibodies (ICAs) are associated with type 1 diabetes (T1D), an autoimmune endocrine disorder. ICAs may be present years before the onset of clinical symptoms. To calculate Juvenile Diabetes Foundation (JDF) units: multiply the titer x 5 (1:8 8 x 5 = 40 JDF Units).
Laboratories.