Ordering Recommendations

Use to stratify the risk of aggressive prostate cancer in individuals 45 years or older with elevated prostate-specific antigen (PSA) for whom biopsy is being considered. This test should not be ordered if (1) prostate cancer was previously diagnosed; (2) digital rectal exam was performed within the last 4 days; (3) any procedure or therapy was used to treat symptomatic benign prostatic hyperplasia (BPH) within the past 6 months; (4) any invasive, urologic procedure that may be associated with a secondary PSA evaluation was performed within the past 6 months; (5) 5-alpha reductase inhibitor (5-ARI) therapy, such as Avodart (dutasteride) or Proscar (finasteride), was administered within the past 6 months.

Collect

Serum separator tube (SST).

Specimen Preparation

Transfer 4 mL serum to an ARUP standard transport tube. (Min: 3 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Frozen serum separator tubes (SST).

Remarks

Biopsy history, digital rectal exam (DRE) results, and clinical indication for ordering are required.

Stability (from collection to initiation)

Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 1 month

Referral Lab

Laboratories.

Lab Section

Send-out Lab

Performing Lab

ARUP Reference Partner

Methodology

Electrochemiluminescent Immunoassay (ECLIA)

Performed

Varies

Reported

3-6 days

Synonyms

  • 4K Prostate Screen; Prostate test
  • Kallikrein score

Notes

4 Kallikrein Biomarkers: Total PSA, free PSA, percent free PSA, intact PSA, and hK2. A digital rectal exam (DRE) is required and submissions should indicate  "nodule" or "no nodule." Test should not be ordered if DRE has been performed within the last 4 days or if biopsy history is positive. DREs performed after collection of specimen are acceptable.

Reference Interval

By report

CPT Codes

81539

LOINC

  • 66117-3
  • 10205-3
  • 19146-0
  • 83112-3
  • 83113-1
  • 12841-3
  • 104720-8

Order Type (Individual or Group)

G

Group Test Information

Result Test ID Reportable Result Test Name Result Type Type (Alpha or Numeric) Prompt Test
4KBIH Y 4K BIOPSY HISTORY I A O
4KDRE Y 4K DIGITAL RECTAL EXAM I A O
4KSCO Y 4K SCORE I A  
4KPST Y 4K PSA, TOTAL I A  
4KPSF Y 4K PSA, FREE I A  
4KPPF Y 4K PSA, PERCENT FREE I A  

Prompt Test

4KBIH - Response Options (Case Sensititive)
1. NO BIOPSY
2. NEGATIVE

4KDRE - Response Options (Case Sensititive)
1. NOT PROVIDED
2. NOT PERFORMED
3. NO NODULE
4. NODULE
 

CPT Codes

81539

LOINC

  • 66117-3
  • 10205-3
  • 19146-0
  • 83112-3
  • 83113-1
  • 12841-3
  • 104720-8

Pricing

Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu
Specimen Requirements

Ordering Recommendations

Use to stratify the risk of aggressive prostate cancer in individuals 45 years or older with elevated prostate-specific antigen (PSA) for whom biopsy is being considered. This test should not be ordered if (1) prostate cancer was previously diagnosed; (2) digital rectal exam was performed within the last 4 days; (3) any procedure or therapy was used to treat symptomatic benign prostatic hyperplasia (BPH) within the past 6 months; (4) any invasive, urologic procedure that may be associated with a secondary PSA evaluation was performed within the past 6 months; (5) 5-alpha reductase inhibitor (5-ARI) therapy, such as Avodart (dutasteride) or Proscar (finasteride), was administered within the past 6 months.

Collect

Serum separator tube (SST).

Specimen Preparation

Transfer 4 mL serum to an ARUP standard transport tube. (Min: 3 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Frozen serum separator tubes (SST).

Remarks

Biopsy history, digital rectal exam (DRE) results, and clinical indication for ordering are required.

Stability (from collection to initiation)

Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 1 month

Referral Lab

Laboratories.
Testing

Lab Section

Send-out Lab

Performing Lab

ARUP Reference Partner

Methodology

Electrochemiluminescent Immunoassay (ECLIA)

Performed

Varies

Reported

3-6 days

Synonyms

  • 4K Prostate Screen; Prostate test
  • Kallikrein score

Notes

4 Kallikrein Biomarkers: Total PSA, free PSA, percent free PSA, intact PSA, and hK2. A digital rectal exam (DRE) is required and submissions should indicate  "nodule" or "no nodule." Test should not be ordered if DRE has been performed within the last 4 days or if biopsy history is positive. DREs performed after collection of specimen are acceptable.
Result Interpretation

Reference Interval

By report
Coding

CPT Codes

81539

LOINC

  • 66117-3
  • 10205-3
  • 19146-0
  • 83112-3
  • 83113-1
  • 12841-3
  • 104720-8
URM Labs Internal
Test Build

Order Type (Individual or Group)

G

Group Test Information

Result Test ID Reportable Result Test Name Result Type Type (Alpha or Numeric) Prompt Test
4KBIH Y 4K BIOPSY HISTORY I A O
4KDRE Y 4K DIGITAL RECTAL EXAM I A O
4KSCO Y 4K SCORE I A  
4KPST Y 4K PSA, TOTAL I A  
4KPSF Y 4K PSA, FREE I A  
4KPPF Y 4K PSA, PERCENT FREE I A  

Prompt Test

4KBIH - Response Options (Case Sensititive)
1. NO BIOPSY
2. NEGATIVE

4KDRE - Response Options (Case Sensititive)
1. NOT PROVIDED
2. NOT PERFORMED
3. NO NODULE
4. NODULE
 

CPT Codes

81539

LOINC

  • 66117-3
  • 10205-3
  • 19146-0
  • 83112-3
  • 83113-1
  • 12841-3
  • 104720-8

Pricing

Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu

Important Information

Lab Section
Send-out Lab
Restricted Test Information
RESTRICTED TEST: This test is restricted to board-certified, subspecialty trained physicians with Staff Privileges at Strong Memorial Hospital, Highland Hospital or F.F. Thompson Hospital. For exceptions: Please refer to the LDC Appeal Process.

ARUP Consult®

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