Use this mass spectrometry test to measure a wide range of estradiol concentrations. Most useful when low estradiol concentrations are expected, regardless of the patient’s sex assigned at birth. Use to monitor estradiol in individuals on estrogen-suppressing hormone therapies (eg, aromatase inhibitors or testosterone).To compare this test to other estrogen tests, refer to the ARUP Estrogen Tests Comparison table.
Collect
Serum separator tube, lavender (EDTA), pink (K2EDTA) or green (sodium or lithium heparin).
Specimen Preparation
Separate serum or plasma from cells within 2 hours after collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL) Indicate age and sex of patient on test request form AND specimen tube.
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-5 days
Synonyms
Estradiol (E2) (Estradiol, Males, Children or Postmenopausal Females, by Tandem Mass Spectrometry)
Ultrasensitive Estradiol
Estradiol (E2)
Reference Interval
Components
Reference Interval
Estradiol by Mass Spec
Age
Male (pg/mL)
Female (pg/mL)
7-9 years
Less than 7.0
Less than 36.0
10-12 years
Less than 11.0
1.0-87.0
13-15 years
1.0-36.0
9.0-249.0
16-17 years
3.0-34.0
2.0-266.0
18 years and older
10.0-42.0
Premenopausal Early Follicular: 30.0-100.0 Late Follicular: 100.0-400.0 Luteal: 50.0-150.0
Postmenopausal: 2.0-21.0
Tanner Stage I
Less than 8.0
Less than 56.0
Tanner Stage II
Less than 10.0
2.0-133.0
Tanner Stage III
1.0-35.0
12.0-277.0
Tanner Stage IV-V
3.0-35.0
2.0-259.0
Interpretive Data
For a complete set of all established reference intervals, refer to ltd.aruplab.com/Tests/Pub/0093247.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
CPT Codes
82670
LOINC
35384-7
Order Type (Individual or Group)
I
Result Test ID
ESTMS
Reportable?
Y
Result Test Name
ESTRADIOL BY TMS
Result Type (Individual or Group)
I
Type (Alpha or Numeric)
A
Text
SEPARATE FROM CELLS WITHIN 2 HOURS
CPT Codes
82670
LOINC
35384-7
Pricing
Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu
Specimen Requirements
Ordering Recommendations
Use this mass spectrometry test to measure a wide range of estradiol concentrations. Most useful when low estradiol concentrations are expected, regardless of the patient’s sex assigned at birth. Use to monitor estradiol in individuals on estrogen-suppressing hormone therapies (eg, aromatase inhibitors or testosterone).To compare this test to other estrogen tests, refer to the ARUP Estrogen Tests Comparison table.
Collect
Serum separator tube, lavender (EDTA), pink (K2EDTA) or green (sodium or lithium heparin).
Specimen Preparation
Separate serum or plasma from cells within 2 hours after collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL) Indicate age and sex of patient on test request form AND specimen tube.
Storage/Transport Temperature
Refrigerated.
Stability (from collection to initiation)
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-5 days
Synonyms
Estradiol (E2) (Estradiol, Males, Children or Postmenopausal Females, by Tandem Mass Spectrometry)
Ultrasensitive Estradiol
Estradiol (E2)
Result Interpretation
Reference Interval
Components
Reference Interval
Estradiol by Mass Spec
Age
Male (pg/mL)
Female (pg/mL)
7-9 years
Less than 7.0
Less than 36.0
10-12 years
Less than 11.0
1.0-87.0
13-15 years
1.0-36.0
9.0-249.0
16-17 years
3.0-34.0
2.0-266.0
18 years and older
10.0-42.0
Premenopausal Early Follicular: 30.0-100.0 Late Follicular: 100.0-400.0 Luteal: 50.0-150.0
Postmenopausal: 2.0-21.0
Tanner Stage I
Less than 8.0
Less than 56.0
Tanner Stage II
Less than 10.0
2.0-133.0
Tanner Stage III
1.0-35.0
12.0-277.0
Tanner Stage IV-V
3.0-35.0
2.0-259.0
Interpretive Data
For a complete set of all established reference intervals, refer to ltd.aruplab.com/Tests/Pub/0093247.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Coding
CPT Codes
82670
LOINC
35384-7
URM Labs Internal
Test Build
Order Type (Individual or Group)
I
Result Test ID
ESTMS
Reportable?
Y
Result Test Name
ESTRADIOL BY TMS
Result Type (Individual or Group)
I
Type (Alpha or Numeric)
A
Text
SEPARATE FROM CELLS WITHIN 2 HOURS
CPT Codes
82670
LOINC
35384-7
Pricing
Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu
Laboratories.