Patient Preparation

Pre-dose (trough) levels should be drawn.

Collect

Lavender (EDTA) 3 mL whole blood

Storage/Transport Temperature

Refrigerated/Room temperature

Unacceptable Conditions

Serum or plasma. Clotted specimens.

Stability (from collection to initiation)

Ambient: 7 days; Refrigerated 14 days; Frozen 1 month

Minimum Requirements

0.5 mL Whole Blood (EDTA)

Test Barcode Number

42235

Lab Section

Toxicology

Methodology

Liquid Chromatography-Tandem Mass Spectrometry 
Test developed and characteristics determined by UR Medicine Labs

Performed

Sun-Sat cut-off 2pm

Reported

Within 48 hours from receipt

Synonyms

  • Sandimmune(R)
  • Gengraf(R)
  • Restasis
  • Neoral(R)
  • Cyclosporine

Performing Laboratory Website (click below)

Reference Interval

Results are reported with the following reference range:

50.0 - 306 ng/mL

Critical value high:  ≥ 450 ng/ml

Ranges for immunosupressant drugs are specific to clinical protocol and published ranges may not be applicable to all patient populations.  The following range is based upon the recommendations of Transplant and Pharmacy services at Strong Memorial Hospital, according to the transplantation protocols in effect at that institution.

NOTE: Immunosuppressant blood levels must be interpreted in the specific context of the patient, taking into account various risk factors and clinical variables.

Interpretive Data

Because each patient is regarded as unique in the handling of this potent immunosuppressive agent, there is no standard reference range for Cyclosporine A. The complexity of the clinical state, individual differences in sensitivity to the immunosuppressive and nephrotoxic effects of CsA, the co-administration of other  immunosuppressant, the type of transplant, time post-transplant and a number of other factors will cause different requirements for optimal whole blood level of CsA. Individual whole blood CsA cannot be used as the sole indicator for making changes in the treatment regimen. Each patient should be thoroughly evaluated clinically before treatment adjustments are made and each user must establish his/her own ranges based on these clinical experiences.

CPT Codes

80158

LOINC Mapping

55805-6

Order Type (Individual or Group)

I

Result Test ID

CSAM

Reportable?

Y

Result Test Name

CYCLOSPORIN A

Result Type (Individual or Group)

I

Type (Alpha or Numeric)

N

Text

DRAW TROUGH LEVEL 30 MINUTES BEFORE DOSE.

CPT Codes

80158

LOINC Mapping

55805-6

Pricing

Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu
Specimen Requirements

Patient Preparation

Pre-dose (trough) levels should be drawn.

Collect

Lavender (EDTA) 3 mL whole blood

Storage/Transport Temperature

Refrigerated/Room temperature

Unacceptable Conditions

Serum or plasma. Clotted specimens.

Stability (from collection to initiation)

Ambient: 7 days; Refrigerated 14 days; Frozen 1 month

Minimum Requirements

0.5 mL Whole Blood (EDTA)

Test Barcode Number

42235
Testing

Lab Section

Toxicology

Methodology

Liquid Chromatography-Tandem Mass Spectrometry 
Test developed and characteristics determined by UR Medicine Labs

Performed

Sun-Sat cut-off 2pm

Reported

Within 48 hours from receipt

Synonyms

  • Sandimmune(R)
  • Gengraf(R)
  • Restasis
  • Neoral(R)
  • Cyclosporine

Performing Laboratory Website (click below)

Result Interpretation

Reference Interval

Results are reported with the following reference range:

50.0 - 306 ng/mL

Critical value high:  ≥ 450 ng/ml

Ranges for immunosupressant drugs are specific to clinical protocol and published ranges may not be applicable to all patient populations.  The following range is based upon the recommendations of Transplant and Pharmacy services at Strong Memorial Hospital, according to the transplantation protocols in effect at that institution.

NOTE: Immunosuppressant blood levels must be interpreted in the specific context of the patient, taking into account various risk factors and clinical variables.

Interpretive Data

Because each patient is regarded as unique in the handling of this potent immunosuppressive agent, there is no standard reference range for Cyclosporine A. The complexity of the clinical state, individual differences in sensitivity to the immunosuppressive and nephrotoxic effects of CsA, the co-administration of other  immunosuppressant, the type of transplant, time post-transplant and a number of other factors will cause different requirements for optimal whole blood level of CsA. Individual whole blood CsA cannot be used as the sole indicator for making changes in the treatment regimen. Each patient should be thoroughly evaluated clinically before treatment adjustments are made and each user must establish his/her own ranges based on these clinical experiences.
Coding

CPT Codes

80158

LOINC Mapping

55805-6
URM Labs Internal
Test Build

Order Type (Individual or Group)

I

Result Test ID

CSAM

Reportable?

Y

Result Test Name

CYCLOSPORIN A

Result Type (Individual or Group)

I

Type (Alpha or Numeric)

N

Text

DRAW TROUGH LEVEL 30 MINUTES BEFORE DOSE.

CPT Codes

80158

LOINC Mapping

55805-6

Pricing

Refer to Lab Account Manager. email: labservicesoutreach@urmc.rochester.edu